推薦產品
生物源
mouse
品質等級
共軛
unconjugated
抗體表格
ascites fluid
抗體產品種類
primary antibodies
無性繁殖
33/2, monoclonal
分子量
antigen (human cathepsin L) 25 kDa
antigen (human procathepsin L) 42 kDa
包含
15 mM sodium azide
物種活性
mouse, mink, human, rat
技術
immunohistochemistry (frozen sections): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1:200 using whole cell extract of a cultured mink lung cell line
同型
IgG1
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CTSL1(1514)
mouse ... Ctsl(13039)
rat ... Ctsl1(25697)
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一般說明
Cathepsin L is a cysteine protease and is secreted by numerous transformed cells in its inactive pre-form. It is ubiquitously expressed and is localized in nucleus. Cathepsin L have substrate interacting region located in L and R domain loops.
特異性
Reacts specifically with native and denatured forms of human cathepsin L and procathepsin L. Recognizes an epitope within amino acid residues GYGFEST (265-271 in procathepsin L and 169-175 in the mature cathepsin L molecule). The antibody may be used for the suppression of the malignant growth of myeloma cells. Cross-reactivity is observed with rat cathepsin L (strong), mouse procathepsin L (weak) and mink cathepsin and procathepsin L. Does not cross-react with human cathepsin types B, D, H and S, procathepsins B and D, rat cathepsin B, and mouse procathepsins B and D.
免疫原
procathepsin L isolated from the human lung cancer cell line EPLC 32M1.
生化／生理作用
Cathepsin L expression is correlated with the metastatic potential of transformed cells. Cathepsin L is capable of degrading protein constituents of the extracellular matrix, this enzyme is thought to play a crucial role in tumor progression, metastasis and other disorders where the destruction of the matrix is the major cause of disease.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Cathepsin-L influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number
Lombardi G, et al.
Journal of Immunology, 174(11), 7022-7032 (2005)
Cysteine cathepsins: from structure, function and regulation to new frontiers
Turk V, et al
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1824(1), 68-88 (2012)
Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation
Goulet B, et al.
Molecular Cancer Research, 5(9), 899-907 (2007)
Cathepsin L1, the Major Protease Involved in Liver Fluke (Fasciola hepatica) virulence propeptide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells
Collins PR, et al.
Test, 279(17), 17038-17046 (2004)
Marouan Abouhamed et al.
American journal of physiology. Renal physiology, 290(6), F1525-F1533 (2006-02-02)
The H+-coupled polyligand transport protein divalent metal transporter 1 (DMT1) plays a key role in mammalian iron homeostasis. It has a widespread pattern of expression including tissues associated with iron acquisition and storage. Interestingly, it is also highly expressed in
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