C2499

CP-339818

≥98% (HPLC)

• 同義詞: N-[1-(phenylmethyl)-4(1H)-quinolinylidene]-1-pentanamine hydrochloride
• 經驗公式（希爾表示法）: C₂₁H₂₄N₂ · HCl
• CAS號碼: 478341-55-8
• 分子量：: 340.89
• MDL號碼: MFCD09878238
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329775008
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to off-white
• 溶解度: DMSO: >10 mg/mL
• 起源: Wyeth
• 儲存溫度: 2-8°C
• SMILES 字串: Cl.CCCCC\N=C1/C=CN(Cc2ccccc2)c3ccccc13
• InChI: 1S/C21H24N2.ClH/c1-2-3-9-15-22-20-14-16-23(17-18-10-5-4-6-11-18)21-13-8-7-12-19(20)21;/h4-8,10-14,16H,2-3,9,15,17H2,1H3;1H/b22-20+;
• InChI 密鑰: JIRISCAPZWLWCG-QPNALZDCSA-N

描述

生化／生理作用

CP-338818 blocks both Kv1.3 and Kv1.4. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain cells. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. CP-339818 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. CP-339818 is also valuable for the study of Kv1.4 function.

特點和優勢

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable