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About This Item
線性公式:
C32H46N5O11F
CAS號碼:
分子量：:
695.73
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.77
推薦產品
生物源
synthetic (organic)
品質等級
化驗
≥95%
形狀
powder
顏色
white
溶解度
DMSO: soluble
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
COC(=O)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)OC)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(C)C)C(=O)CF
InChI
1S/C32H46FN5O11/c1-17(2)26(30(44)34-19(5)28(42)35-21(23(39)15-33)13-24(40)47-6)37-29(43)22(14-25(41)48-7)36-31(45)27(18(3)4)38-32(46)49-16-20-11-9-8-10-12-20/h8-12,17-19,21-22,26-27H,13-16H2,1-7H3,(H,34,44)(H,35,42)(H,36,45)(H,37,43)(H,38,46)/t19-,21-,22-,26-,27-/m0/s1
InChI 密鑰
ANTIWMNLIROOQF-IREHUOSBSA-N
基因資訊
human ... CASP2(835)
mouse ... CASP2(12366)
rat ... CASP2(64314)
Amino Acid Sequence
Z-Val-Asp-OMe-Val-Ala-Asp-OMe-FMK
生化／生理作用
A cell-permeable inhibitor of caspase-2, which exhibits competitive and irreversible inhibition.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Wolfgang W Quitschke
PloS one, 7(6), e39568-e39568 (2012-07-07)
Curcumin preparations typically contain a mixture of polyphenols, collectively referred to as curcuminoids. In addition to the primary component curcumin, they also contain smaller amounts of the co-extracted derivatives demethoxycurcumin and bisdemethoxycurcumin. Curcuminoids can be differentially solubilized in serum, which
Aitziber Buqué et al.
Molecular cancer, 11, 25-25 (2012-04-28)
Metastatic melanoma is a lethal skin cancer and its incidence is rising every year. It represents a challenge for oncologist, as the current treatment options are non-curative in the majority of cases; therefore, the effort to find and/or develop novel
L Gorvel et al.
Cell death & disease, 1, e34-e34 (2011-03-03)
Tropheryma whipplei, the etiological agent of Whipple's disease, is an intracellular bacterium that infects macrophages. We previously showed that infection of macrophages results in M2 polarization associated with induction of apoptosis and interleukin (IL)-16 secretion. In patients with Whipple's disease
Patrick Y Kim et al.
Apoptosis : an international journal on programmed cell death, 18(5), 639-651 (2013-02-14)
TRIM16 exhibits tumour suppressor functions by interacting with cytoplasmic vimentin and nuclear E2F1 proteins in neuroblastoma and squamous cell carcinoma cells, reducing cell migration and replication. Reduced TRIM16 expression in a range of human primary malignant tissues correlates with increased
Alex Chernyavsky et al.
International immunopharmacology, 80, 106149-106149 (2020-01-21)
Pemphigus vulgaris (PV) is a potentially lethal mucocutaneous blistering disease characterized by IgG autoantibodies (AuAbs) binding to epidermal keratinocytes and inducing a devastating blistering disease affecting oral and/or esophageal surfaces and, sometimes, also the skin. Anti-keratinocyte AuAbs developed by the
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