B7272

4-溴钙离子载体A23187

powder

• 同義詞: 4-溴-A23187, 4-溴-钙霉素
• 經驗公式（希爾表示法）: C₂₉H₃₆BrN₃O₆
• CAS號碼: 76455-48-6
• 分子量：: 602.52
• MDL號碼: MFCD00077667
• 分類程式碼代碼: 12352202
• PubChem物質ID: 24891982
• NACRES: NA.77

屬性

• 形狀: powder
• 品質等級: 200
• 顏色: yellow
• 溶解度: ethanol: 20 mg/mL; DMSO: soluble
• 儲存溫度: 2-8°C
• SMILES 字串: CNc1c(Br)cc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@@H]([C@H](C)C[C@H]4C)[C@H](C)C(=O)c5ccc[nH]5)nc2c1C(O)=O
• InChI: 1S/C29H36BrN3O6/c1-14-8-9-29(16(3)11-15(2)27(39-29)17(4)26(34)19-7-6-10-32-19)38-20(14)13-22-33-25-21(37-22)12-18(30)24(31-5)23(25)28(35)36/h6-7,10,12,14-17,20,27,31-32H,8-9,11,13H2,1-5H3,(H,35,36)/t14-,15-,16-,17-,20-,27+,29+/m1/s1
• InChI 密鑰: LDXQFZZGVTWFCF-FHYGWRBKSA-N

描述

應用

4-Bromo-calcium Ionophore A23187 has been used for the activation of Ca²⁺/calmodulin kinase II (CaMKII) in HeLa cell line. It has also been used as a calcium mobilizer to investigate its effect on superoxide dismutase 1 (SOD1) aggregates in VSC 4.1 cells.

非荧光Ca²⁺离子载体，可用于通过荧光探针校准细胞质游离Ca²⁺的定量。

生化／生理作用

4-Bromo-calcium Ionophore A23187 is a modulator of apoptosis. It inhibits apoptosis in a concentration dependent manner in neutrophils which are aging in vitro and increases the intracellular Ca²⁺ levels.

其他說明

Analog of calcium ionophore A23187

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302 + H312 + H332,H315,H319,H335
• 防範說明: P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• 危險分類: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 13 - Non Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves