推薦產品
product name
米酵菌酸 溶液, from Pseudomonas cocovenenans, ≥95% (HPLC), ~1 mg/mL
生物源
Pseudomonas cocovenenans
品質等級
化驗
≥95% (HPLC)
形狀
solution
濃度
~1 mg/mL
運輸包裝
wet ice
儲存溫度
−20°C
SMILES 字串
CO[C@H](C/C=C\C=C\CC\C=C\C[C@H](C)\C=C\C(CC(O)=O)=C/C(O)=O)\C(C)=C/C=C(\C)C(O)=O
InChI
1S/C28H38O7/c1-21(15-18-24(19-26(29)30)20-27(31)32)13-11-9-7-5-6-8-10-12-14-25(35-4)22(2)16-17-23(3)28(33)34/h6,8-12,15-19,21,25H,5,7,13-14,20H2,1-4H3,(H,29,30)(H,31,32)(H,33,34)/b8-6+,11-9+,12-10-,18-15+,22-16-,23-17+,24-19+/t21-,25+/m0/s1
InChI 密鑰
SHCXABJSXUACKU-WUTQZGRKSA-N
應用
米酵菌酸溶液已被用作腺嘌呤核苷酸转运蛋白(ANT)抑制剂，以发现抑制完整T98G细胞中的氧化磷酸化的其他方法。它还被用作通透转运孔复合物(PTPC)孔抑制剂，以及探索PTPC诱导细胞凋亡作用的工具。
生化／生理作用
其是一种抗凋亡剂，它可以预防NMDA受体诱导的神经细胞凋亡， 延长病毒载体感染后凋亡细胞的存活，并且可在T细胞中消除由过氧化氢诱导的细胞凋亡。它是腺嘌呤核苷酸转位酶的抑制剂，其是线粒体通透性转换（MPT）孔复合物的组分。米酵菌酸可防止线粒体去极化、肿胀、线粒体外膜破裂、以及细胞色素c等凋亡蛋白的释放。该现象在Stururosporine诱导的Jurkat细胞凋亡过程中，和在TNF-α和乙醇处理后经历凋亡的HepG2中观察到。
特點和優勢
该化合物是细胞凋亡研究的推荐产品。点击此处，了解更多精选的细胞凋亡产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问sigma.com/discover-bsm。
其他說明
椰毒假单胞菌 的毒性原理。
外觀
溶于0.01M Tris缓冲液（pH 7.5）中的溶液。
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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