B4311

BF-170 hydrochloride

≥98% (HPLC), solid

• 同義詞: 2-(4-aminophenyl)quinoline hydrochloride, NSC 168387 hydrochloride
• 經驗公式（希爾表示法）: C₁₅H₁₂N₂ · HCl
• CAS號碼: 22191-97-5
• 分子量：: 256.73
• MDL號碼: MFCD08705340
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24891766
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 儲存條件: desiccated; protect from light; under inert gas
• 顏色: orange
• 溶解度: H₂O: 10 mg/mL
• 儲存溫度: −20°C
• SMILES 字串: Cl[H].Nc1ccc(cc1)-c2ccc3ccccc3n2
• InChI: 1S/C15H12N2.ClH/c16-13-8-5-12(6-9-13)15-10-7-11-3-1-2-4-14(11)17-15;/h1-10H,16H2;1H
• InChI 密鑰: UYYPMQOFLJHJAW-UHFFFAOYSA-N

描述

生化／生理作用

BF-170 is a new probe for neurofibrillary tangles (tau fibrils). It exhibits greater binding affinity to tau than to Aβ fibrils, EC₅₀ = 221 nM vs. EC₅₀ = 786 nM (Ki for Aβ > 5,000 nM). BF-170 demonstrates fast clearance from the brain; clearly visualizes neurofibrillary tangles, neuropil threads, and paired helical filament-type neuritis. BF-70 may become one of the candidate compounds for in vivo imaging of tau pathology associated with Alzheimer′s disease and is a useful tool in distinguishing among tau and Aβ fibrils specifically in AD.

注意

Product is air sensitive, store under inert gas.

安全資訊

• 象形圖: GHS05,GHS07
• 訊號詞: Danger
• 危險聲明: H302,H315,H318,H335
• 防範說明: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• 危險分類: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Faceshields, Gloves