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Key Documents

B107

Sigma-Aldrich

L-BMAA 盐酸盐

≥97% (NMR), powder

同義詞:

S(+)-2-氨基-3-(甲基氨基)丙酸 盐酸盐

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About This Item

經驗公式(希爾表示法):
C4H10N2O2 · HCl
CAS號碼:
分子量::
154.60
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.32

化驗

≥97% (NMR)

形狀

powder

光學活性

[α]/D +21 to +31°, c = 0.5 M in 0.1 M HCl(lit.)

儲存條件

desiccated

顏色

white to beige

溶解度

H2O: soluble (solutions may be stored for several days at 4 °C)

儲存溫度

−20°C

SMILES 字串

Cl.CNC[C@H](N)C(O)=O

InChI

1S/C4H10N2O2.ClH/c1-6-2-3(5)4(7)8;/h3,6H,2,5H2,1H3,(H,7,8);1H/t3-;/m0./s1

InChI 密鑰

VDXYGASOGLSIDM-DFWYDOINSA-N

一般說明

L-BMAA 盐酸盐/ β-N-甲基氨基-1-丙氨酸(BMAA)是一种蓝藻神经毒素(cyanobacterial neurotoxin)。

應用

L-BMAA 盐酸盐可用作标准品,用于比较沙漠结皮(desert crust)材料的β-N-甲基氨基-1-丙氨酸(BMAA)异构体分析中的所有样品。它也已被用作f/2+Sii培养基的添加剂,用于处理三角藻(Phaeodyylum tricornutum)和威氏海链藻 (Thalassiosira weissflogii)细胞,以研究其对它们的作用。

生化/生理作用

L-BMAA盐酸盐有助于阻止硫酸乙酰肝素加入磷脂酰肌醇蛋白聚糖。它具有不同寻常的谷氨酸受体结合特性。它可引起肌萎缩性侧索硬化症/ Lou Gehrig′病。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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Neurotoxic amino acids and their isomers in desert environments
Metcalf JS, et al.
Journal of arid environments, 140-144 (2015)
David A Davis et al.
Journal of neuropathology and experimental neurology, 79(4), 393-406 (2020-02-23)
The early neuropathological features of amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) are protein aggregates in motor neurons and microglial activation. Similar pathology characterizes Guamanian ALS/Parkinsonism dementia complex, which may be triggered by the cyanotoxin β-N-methylamino-l-alanine (BMAA). We report here the
Olga A Koksharova et al.
Toxins, 12(6) (2020-06-10)
All cyanobacteria produce a neurotoxic non-protein amino acid β-N-methylamino-L-alanine (BMAA). However, the biological function of BMAA in the regulation of cyanobacteria metabolism still remains undetermined. It is known that BMAA suppresses the formation of heterocysts in diazotrophic cyanobacteria under nitrogen
2-Amino-β-methylamino-propionc acid, a new amino acid from seeds of Cycas circinali.
Vega, et al.
Psychochemistry, 6, 759-762 (1967)
Johan Eriksson et al.
Amino acids, 36(1), 43-48 (2008-01-12)
Two different assays have been developed and used in order to investigate the optimal conditions for derivatization and detection of acid beta-N-methyl-amino-L-alanine (BMAA) in a cyanobacterial sample. BMAA was extracted from cyanobacterial cultures both from the cytosolic ("free") fraction and

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