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B0936

Sigma-Aldrich

BRL 50481

≥98% (HPLC), solid

同義詞:

5-Nitro-2,N,N-trimethylbenzenesulfonamide

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About This Item

經驗公式(希爾表示法):
C9H12N2O4S
CAS號碼:
分子量::
244.27
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

solid

顏色

white to off-white

溶解度

DMSO: >10 mg/mL
H2O: insoluble

起源

GlaxoSmithKline

儲存溫度

2-8°C

SMILES 字串

CN(C)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O

InChI

1S/C9H12N2O4S/c1-7-4-5-8(11(12)13)6-9(7)16(14,15)10(2)3/h4-6H,1-3H3

InChI 密鑰

IFIUFCJFLGCQPH-UHFFFAOYSA-N

基因資訊

生化/生理作用

BRL 50481 is a potent and selective PDE7 inhibitor (IC50 = 260 nM).

特點和優勢

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律資訊

Sold for research purposes under agreement from GlaxoSmithKline

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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Lucie Jiraskova et al.
Molecular pharmaceutics, 15(7), 2732-2741 (2018-05-22)
Equilibrative ( SLC29A) and concentrative ( SLC28A) nucleoside transporters contribute to proper placental development and mediate uptake of nucleosides/nucleoside-derived drugs. We analyzed placental expression of SLC28A mRNA during gestation. Moreover, we studied in choriocarcinoma-derived BeWo cells whether SLC29A and SLC28A
Maike Monzel et al.
FEBS letters, 588(18), 3469-3474 (2014-08-17)
The degradation and biological role of the cyclic pyrimidine nucleotide cCMP is largely elusive. We investigated nucleoside 3',5'-cyclic monophosphate (cNMP) specificity of six different recombinant phosphodiesterases (PDEs) by using a highly-sensitive HPLC-MS/MS detection method. PDE7A1 was the only enzyme that

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