A8356

APR 101

≥98% (HPLC), solid

• 同義詞: (2R)-2-[([1,1′-Biphenyl]-4-ylsulfonyl)(1-methylethoxy)amino]-N-hydroxy-3-methyl-butanamide, (R)-N-Hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamide
• 經驗公式（希爾表示法）: C₂₀H₂₆N₂O₅S
• CAS號碼: 849773-64-4
• 分子量：: 406.50
• MDL號碼: MFCD09753277
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329770956
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: solid
• 溶解度: DMSO: >20 mg/mL; H₂O: insoluble
• 儲存溫度: −20°C
• SMILES 字串: CC(C)ON([C@H](C(C)C)C(=O)NO)S(=O)(=O)c1ccc(cc1)-c2ccccc2
• InChI: 1S/C20H26N2O5S/c1-14(2)19(20(23)21-24)22(27-15(3)4)28(25,26)18-12-10-17(11-13-18)16-8-6-5-7-9-16/h5-15,19,24H,1-4H3,(H,21,23)/t19-/m1/s1
• InChI 密鑰: DGZZVIWCMGVHGV-LJQANCHMSA-N

描述

應用

ARP 101 is a MMP-2 selective inhibitor. ARP 101 has diverse physiological roles including wound healing, cancer metastasis, angiogenesis, tissue remodeling in development, and embryogenesis.

生化／生理作用

ARP 101 is a MMP-2 selective inhibitor (Gelatinase A, EC 3.4.24.24; TBE-1; LG4A; MONA; Type IV Collagenase). ARP 101 has diverse physiological roles including wound healing, cancer metastasis, angiogenesis, tissue remodeling in development and embryogenesis. IC₅₀ = 0.81 nM on MMP-2.

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301
• 防範說明: P264 - P270 - P301 + P310 - P405 - P501
• 危險分類: Acute Tox. 3 Oral
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges