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Key Documents

A7856

Sigma-Aldrich

阿西莫司

≥99% (TLC)

同義詞:

2-羧基-5-甲基吡嗪4-氧化物, 5-甲基吡嗪羧酸4-氧化物

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About This Item

經驗公式(希爾表示法):
C6H6N2O3
CAS號碼:
分子量::
154.12
EC號碼:
分類程式碼代碼:
12352205
NACRES:
NA.79

化驗

≥99% (TLC)

形狀

powder

顏色

off-white to faint yellow

mp

177-180 °C

儲存溫度

2-8°C

InChI

1S/C6H6N2O3/c1-4-2-7-3-5(6(9)10)8(4)11/h2-3H,1H3,(H,9,10)

InChI 密鑰

DNRXJHATQULEHC-UHFFFAOYSA-N

生化/生理作用

阿昔莫司又称氧甲吡嗪,是一种烟酸类似物。它可用作抗脂解药和血管扩张剂。阿西莫司可用于胰岛素和生长素释放肽相关的各种代谢研究。它可降低总胆固醇和总甘油三酯,从而有助于治疗高脂血症。
已经研究了烟酸衍生的血管舒张剂的降脂作用。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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Feipeng Jin et al.
Biochemical and biophysical research communications, 428(1), 86-92 (2012-10-13)
Saturated fatty acids (FA) have been linked to an increased risk of cardiovascular disease. The effects of acipimox, a FA-lowering agent, on palmitate- (an important saturated fatty acid) stimulated atherosclerosis remains to be elucidated. We investigated the effects of acipimox
Inflammation and lipid accumulation in xanthoma disseminatum: Therapeutic considerations.
Klaus Eisendle et al.
Journal of the American Academy of Dermatology, 58(2 Suppl), S47-S49 (2008-01-23)
Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus.
Vaag A, et al.
The Journal of Clinical Investigation, 88(4), 1282-1290 (1991)
Lars C Gormsen et al.
European journal of endocrinology, 154(5), 667-673 (2006-04-29)
Concentrations of the orexigenic peptide ghrelin is affected by a number of hormones, which also affect circulating levels of free fatty acids (FFAs). The present study was therefore designed to determine the direct effect of FFAs on circulating ghrelin. Eight
Jara Nedvidkova et al.
Regulatory peptides, 167(1), 134-139 (2011-01-18)
Ghrelin is predominantly produced by the stomach and the growth hormone (GH)-ghrelin feedback loop between the stomach and the pituitary gland has recently been suggested. The disruption of the gut-brain axis might be involved in bulimia nervosa (BN). We investigated

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