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重要文件

A7687

Sigma-Aldrich

芦荟大黄素

≥95% (HPLC)

同義詞:

1,8-二羟基-3-(羟甲基)蒽甲苯, 1,8-二羟基3-羟甲基蒽甲苯, 3-羟甲基白杨嗪, 弹力素

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About This Item

經驗公式(希爾表示法):
C15H10O5
CAS號碼:
分子量::
270.24
Beilstein:
2059062
EC號碼:
MDL號碼:
分類程式碼代碼:
12352205
PubChem物質ID:
NACRES:
NA.79

生物源

plant root (Rheum palmatum)

品質等級

化驗

≥95% (HPLC)

形狀

powder

技術

HPLC: suitable

顏色

yellow to brown

儲存溫度

2-8°C

SMILES 字串

OCc1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1

InChI

1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2

InChI 密鑰

YDQWDHRMZQUTBA-UHFFFAOYSA-N

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一般說明

芦荟大黄素是在芦荟中天然存在的一种羟基蒽醌。

應用

芦荟大黄素已被用作标准品,用于通过高效液相色谱 (HPLC) 分离和鉴定木立芦荟(Aloe arborescens Miller var. natalensis Berger)中的酚类化合物。

生化/生理作用

复方泻药/泻药;通过释放内源性乙酰胆碱来增加肠道平滑肌的收缩。抗肿瘤活性与活性氧簇 (ROS) 产生增加相关,活性氧簇反过来降低线粒体跨膜电位,从而诱导渗透性转换,启动一系列事件,最终导致细胞凋亡。遗传毒性和致突变性似乎是由于芦荟大黄素抑制了拓扑异构酶II的活性。
芦荟大黄素具有抗菌、抗病毒、消炎和保肝作用。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

防範說明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

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存取文件庫

Mildred Acevedo-Duncan et al.
International immunopharmacology, 4(14), 1775-1784 (2004-11-09)
Aloe-emodin (1,8-dihydroy-3-[hydroxymethyl]-anthraquione) purified from Aloe vera leaves has been reported to have antitumor activity. The objectives of our research were to determine how aloe-emodin regulates the cell cycle, cell proliferation and protein kinase C (PKC) during glioma growth and development.
Jun-ming Guo et al.
Acta pharmacologica Sinica, 28(12), 1991-1995 (2007-11-23)
The aim of this study was to investigate the effects of aloe-emodin, a natural compound from the root and rhizome of Rheum palmatum, on the growth of human cervical cancer cells, HeLa. HeLa cells were treated with various concentrations of
Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages
Park MY, et al.
Bioscience, Biotechnology, and Biochemistry, 73(4), 828-832 (2009)
Yiqun Du et al.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 24(2), 746-753 (2019-05-28)
To study the anticancer effects of aloe emodin against the MIAPaCa-2 and PANC-1 human pancreatic adenocarcinoma cancer cell lines by evaluating its effect on autophagic cell death, mitochondrial membrane potential (ΛΨm) loss and cell cycle arrest. The MTT assay was
Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors.
Pecere T, et al.
Cancer Research, 60(11), 2800-2804 (2000)

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