324694

Emodin

A cell-permeable, reversible, substrate competitive and potent p56^lck tyrosine kinase inhibitor (IC₅₀ = 18.5 µM).

• 同義詞: Emodin, 6-Methyl-1,3,8-trihydroxyanthraquinone
• 經驗公式（希爾表示法）: C₁₅H₁₀O₅
• CAS號碼: 518-82-1
• 分子量：: 270.24
• MDL號碼: MFCD00001207
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥90% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: orange
• 溶解度: DMSO: 1 mg/mL; aqueous base: soluble; ethanol: soluble
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
• InChI 密鑰: RHMXXJGYXNZAPX-UHFFFAOYSA-N

描述

一般說明

A cell-permeable, reversible, substrate competitive and potent p56^lck tyrosine kinase inhibitor (IC₅₀ = 18.5 µM). Selectively blocks the growth of v-ras transformed human bronchial epithelial cells (IC₅₀ = 15 µM). Also suppresses HER2/neu tyrosine kinase activity in HER2/neu overexpressing breast cancer cells.

A cell-permeable, reversible, substrate competitive and potent p56^lck tyrosine kinase inhibitor (IC₅₀ = 18.5 µM). Selectively blocks the growth of v-ras transformed human bronchial epithelial cells (IC₅₀ = 14.8 µM) without affecting normal human bronchial epithelial cells, even at a concentration of 370 mM. Reported to act as an inhibitor of Tau aggregation and aid in the disassembly of PHF in vitro and in vivo.

生化／生理作用

Cell permeable: yes

Primary Target
p56^lck tyrosine kinase

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 18.5 µM against p56lck tyrosine kinase

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution in DMSO, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous alkali; reconstitute just prior to use.

其他說明

Pickhardt, M., et al. 2004. J. Biol. Chem.280, 3628.
Zhang, L., and Hung. M.C. 1996. Oncogene 12, 571.
Chan, T.C., et al. 1993. Biochem. Biophys. Res. Commun. 193, 1152.
Jayasuriya, H., et al. 1992. J. Nat. Prod.55, 696.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable