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About This Item
經驗公式（希爾表示法）:
C16H11N3O3
CAS號碼:
分子量：:
293.28
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推薦產品
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
yellow to brown
溶解度
DMSO: ≥10 mg/mL
儲存溫度
2-8°C
SMILES 字串
[O-][N+](=O)c1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
InChI
1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)
InChI 密鑰
OLUKILHGKRVDCT-UHFFFAOYSA-N
基因資訊
rat ... Gsk3b(84027)
應用
Alsterpaullone 已用于稳定 β-catenin。
Alsterpaullone 抑制 GSK-3β、CDK5/p25 和 CDK1/cyclinB。Alsterpaullone 也已被作为抗躁狂药进行研究，用于双相情感障碍急性躁狂期的治疗。
生化／生理作用
Alsterpaullone（ALP）是一种细胞周期蛋白依赖性激酶（CDK）抑制剂。它被认为是第 3 组髓母细胞瘤的治疗药物。Alsterpaullone 调节细胞周期的进程。它可以通过干扰线粒体膜电位来激活 caspase-9，从而阻止细胞周期并刺激癌细胞凋亡。
GSK-3β 和 CDK5/p25; 的有效和选择性抑制剂；CDK1/cyclin B 的有效抑制剂（IC50 = 0.035 μM）。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Michael Trevino et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 240(12), 2673-2679 (2011-11-05)
Although regeneration is widespread among metazoa, the molecular mechanisms have been studied in only a handful of taxa. Of these taxa, fewer still are amenable to studies of embryogenesis. Our understanding of the evolution of regeneration, and its relation to
Tsuneo Takadera et al.
Neurotoxicity research, 21(3), 309-316 (2011-10-19)
In the central nervous system, members of the Src family of tyrosine kinases (SFKs) are widely expressed and are abundant in neurons. The purpose of this study is to examine whether glycogen synthase-3 (GSK-3) is involved in SFK inhibitor-induced apoptosis.
Mikhail Kalinichev et al.
The international journal of neuropsychopharmacology, 14(8), 1051-1067 (2011-01-07)
There is a growing body of evidence suggesting that animal models can be developed to probe the specific domains of bipolar disorder (BD) using the endophenotype approach. Here we tested clinically active antimanic drugs to validate amphetamine-induced hyperactivity in Black
C Schultz et al.
Journal of medicinal chemistry, 42(15), 2909-2919 (1999-07-30)
The paullones represent a novel class of small molecule cyclin-dependent kinase (CDK) inhibitors. To investigate structure-activity relationships and to develop paullones with antitumor activity, derivatives of the lead structure kenpaullone (9-bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one, 4a) were synthesized. Paullones with different substituents in the
Identification of alsterpaullone as a novel small molecule inhibitor to target group 3 medulloblastoma
Faria C C, et al.
Testing, 6(25), 21718-21718 (2015)
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