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Merck
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重要文件

90469

Sigma-Aldrich

(RS)-甲羟戊酸 锂盐

≥96.0% (GC)

同義詞:

(±)-MVA-Li, rac.-MVA-Li, 锂 (±)-3,5-二羟基-3-甲基-戊酸酯, 锂 (±)-3,5-二羟基-3-甲基戊酸酯

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About This Item

經驗公式(希爾表示法):
C6H11O4 · xLi+
CAS號碼:
分子量::
147.15 (free acid basis)
分類程式碼代碼:
12352107
NACRES:
NA.25
化驗:
≥96.0% (GC)
形狀:
solid

品質等級

化驗

≥96.0% (GC)

形狀

solid

成份

lithium, 2.2-4.7%

儲存溫度

2-8°C

InChI

1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)

InChI 密鑰

KJTLQQUUPVSXIM-UHFFFAOYSA-N

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生化/生理作用

甲羟戊酸途径的代谢产物,在甾醇、多萜醇、血红素和泛醌的生物合成中起关键作用。在疾病肿瘤、自身免疫性疾病、动脉粥样硬化和阿尔茨海默病,以及遗传缺陷的甲羟戊酸激酶等研究领域受到关注。

包裝

无底玻璃瓶。内含物在插入的融合锥体内。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Mevalonate pathway is an important cellular metabolic pathway present in all higher eukaryotes and many bacteria. Four enzymes in mevalonate pathway, including MVK, PMK, MDD, and FPPS, play important regulatory roles in cholesterol biosynthesis and cell proliferation. The following methods
Jordi Pérez-Gil et al.
The Biochemical journal, 452(1), 19-25 (2013-04-26)
Isoprenoids are a large family of compounds synthesized by all free-living organisms. In most bacteria, the common precursors of all isoprenoids are produced by the MEP (methylerythritol 4-phosphate) pathway. The MEP pathway is absent from archaea, fungi and animals (including
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Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 34(1), 429-435 (2012-11-28)
Esophageal squamous cell carcinoma (ESCC) is one of the most common lethal tumors in the world. Thus, it is very urgent to develop new therapeutic targets against this disease. The mevalonate (MVA) pathway, paced by its rate-limiting enzyme, hydroxymethylglutaryl coenzyme
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Molecular genetics and metabolism, 107(4), 756-759 (2012-11-14)
Mevalonate kinase deficiency is a rare autosomal recessively inherited organic aciduria with a complex multi-systemic phenotype. We describe two deceased patients with clinically severe mevalonate kinase (MK) deficiency confirmed by MK mutation analysis. The phenotype in our patients ranged from
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Neurochemical research, 38(3), 589-600 (2012-12-28)
Statins, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, have been reported to attenuate amyloid-β peptide (Aβ) production in various cellular models. However, the mechanisms by which statins affect neuronal Aβ production have not yet been clarified. Here, we investigated this issue in

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