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Key Documents

74667

Sigma-Aldrich

硫酸诺尔斯菌素

≥85% (HPLC)

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About This Item

CAS號碼:
MDL號碼:
分類程式碼代碼:
51102829
NACRES:
NA.85

生物源

Streptomyces noursei

品質等級

化驗

≥85% (HPLC)

形狀

solid

顏色

white to light brown

溶解度

H2O: soluble 200 mg/mL

適合性

suitable for (selection agent for molecular genetic research work)

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria
fungi
mycobacteria
mycoplasma
parasites
viruses
yeast

作用方式

protein synthesis | interferes

儲存溫度

2-8°C

一般說明

Chemical structure: peptidyl nucleoside

應用

Noursethricin is used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa and plants.

生化/生理作用

Nourseothricin inhibits biosynthesis and induces miscoding. Resistance to nourseothricin is mediated by the sat1 encoded N-acetyltransferase. Nourseothricin is inactivated by acetylation of the β-amino group of the β-lysin.
Antifungal effective against Candida albicans. Candida species transformed with the gene encoding nourseothricin acetyltransferase (CaNAT1) were resistant to nourseothricin.

包裝

10mg, 100mg

其他說明

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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Adrian J Verster et al.
G3 (Bethesda, Md.), 7(10), 3337-3347 (2017-08-26)
Genes encoding essential components of core cellular processes are typically highly conserved across eukaryotes. However, a small proportion of essential genes are highly taxonomically restricted; there appear to be no similar genes outside the genomes of highly related species. What
Dorota Fennessy et al.
PloS one, 9(5), e97683-e97683 (2014-05-23)
Targeted alteration of the genome lies at the heart of the exploitation of S. pombe as a model system. The rate of analysis is often determined by the efficiency with which a target locus can be manipulated. For most loci
Kristin L Patrick et al.
Cell systems, 7(3), 323-338 (2018-08-06)
Intracellular bacterial pathogens secrete a repertoire of effector proteins into host cells that are required to hijack cellular pathways and cause disease. Despite decades of research, the molecular functions of most bacterial effectors remain unclear. To address this gap, we
Tomokazu Murakawa et al.
Cell reports, 26(2), 338-345 (2019-01-10)
Degradation of mitochondria by selective autophagy, termed mitophagy, contributes to the control of mitochondrial quality. Bcl2-L-13 is a mammalian homolog of Atg32, which is an essential mitophagy receptor in yeast. However, the molecular machinery involved in Bcl2-L-13-mediated mitophagy remains to
Markus Mund et al.
Cell, 174(4), 884-896 (2018-07-31)
Clathrin-mediated endocytosis is an essential cellular function in all eukaryotes that is driven by a self-assembled macromolecular machine of over 50 different proteins in tens to hundreds of copies. How these proteins are organized to produce endocytic vesicles with high precision

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