74155

无活菌素

from Streptomyces sp., ≥97.0% (TLC)

• 同義詞: 铵离子载体
• 經驗公式（希爾表示法）: C₄₀H₆₄O₁₂
• CAS號碼: 6833-84-7
• 分子量：: 736.93
• Beilstein: 76434
• EC號碼: 229-911-3
• 分類程式碼代碼: 51102829
• PubChem物質ID: 24886652
• NACRES: NA.85

屬性

• 生物源: Streptomyces sp.
• 品質等級: 200
• 化驗: ≥97.0% (TLC)
• 形狀: powder
• 顏色: white to faint yellow
• 抗生素活性譜: Gram-positive bacteria
• 作用方式: DNA synthesis | interferes; cell membrane | interferes; enzyme | inhibits
• 儲存溫度: 2-8°C
• SMILES 字串: C[C@H]1C[C@@H]2CC[C@@H](O2)[C@@H](C)C(=O)O[C@H](C)C[C@H]3CC[C@H](O3)[C@H](C)C(=O)O[C@@H](C)C[C@@H]4CC[C@@H](O4)[C@@H](C)C(=O)O[C@H](C)C[C@H]5CC[C@H](O5)[C@H](C)C(=O)O1
• InChI: 1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1-8H3/t21-,22+,23+,24-,25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-
• InChI 密鑰: RMIXHJPMNBXMBU-QIIXEHPYSA-N

描述

一般說明

Chemical structure: macrolide

May contain the homologues monactin and dinactin

應用

Nonactin is used as a neutral lipid membrane soluble ammonium (and potassium) ionophore, as an uncoupler of oxidative phosphorylation, and to inhibit surface expression of certain heat shock proteins (HSP60) .

生化／生理作用

Nonactin is a macrotetrolide that forms complexes with alkali cations, such as potassium and sodium. Nonactin has been reported to inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is a uncoupler of oxidative phosphorylation .

包裝

5 mg

其他說明

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas.Moisturesensitive. Keep in a dry place.

Natural macrotetrolide

安全資訊

• 儲存類別代碼: 13 - Non Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)