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重要文件

64255

Sigma-Aldrich

亚甲基二膦酸

for molecular studies & mass spectrometry

同義詞:

MDP, 亚甲磷酸

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About This Item

線性公式:
CH2[P(O)(OH)2]2
CAS號碼:
分子量::
176.00
Beilstein:
1708494
MDL號碼:
分類程式碼代碼:
12352106
PubChem物質ID:
NACRES:
NA.52

品質等級

形狀

powder

mp

197-199 °C (lit.)
201-205 °C

儲存溫度

2-8°C

SMILES 字串

OP(O)(=O)CP(O)(O)=O

InChI

1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7)

InChI 密鑰

MBKDYNNUVRNNRF-UHFFFAOYSA-N

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一般說明

MDP(亚甲基二膦酸)是ATP的膦酸类似物。

應用

适用于
  • 天然二磷酸盐和三磷酸盐类似物的制备
  • 质谱研究作为分析标准
  • 与炎症相关的分子研究

象形圖

Corrosion

訊號詞

Danger

危險聲明

危險分類

Eye Dam. 1 - Skin Corr. 1B

儲存類別代碼

8A - Combustible corrosive hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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分析證明 (COA)

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J.A. Stock
The Journal of Organic Chemistry, 44, 3997-3997 (1979)
T G Rudd et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 18(9), 872-876 (1977-09-01)
The biologic and imaging characteristics of Tc-99m MDP and Tc-99m PPi were compared in animals and patients using freeze-dried bone-imaging kits. Biodistribution data in rabbits showed Tc-99m MDP had slightly higher bone uptake, significantly lower blood levels, and faster urinary
Phosphonic acid analogs of nucleoside phosphates. I. The synthesis of 5'-adenylyl methylenediphosphonate, a phosphonic acid analog of ATP
Myers TC et al
Journal of the American Chemical Society, 85, 3292-3295 (1963)
R. Engel
Chemical Reviews, 77, 349-349 (1977)
H F Kung et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 19(9), 1027-1031 (1978-09-01)
Bidentate monophosphates--phosphonoacetate (PAA), 2-phosphonoproprionate (PPA), 2-methyl-2-phosphonoproprionate (MPPA), and carbamyl phosphate (CAP)--which are pyrophosphate analogs, were successfully labeled with Sn(II)-reduced [99mTc] pertechnetate in high yield (greater than 95%). Biodistribution studies show that these Tc-99m-labeled monophosphates do localize in bone. At 2

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