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Key Documents

59815

Sigma-Aldrich

1-(4-异硫氰苄基)乙烯基二胺-N,N,N′,N′-四乙酸

~90% (HPLC)

同義詞:

异硫氰苄基-EDTA

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About This Item

經驗公式(希爾表示法):
C18H21N3O8S
CAS號碼:
分子量::
439.44
Beilstein:
8363400
MDL號碼:
分類程式碼代碼:
12352106
PubChem物質ID:
NACRES:
NA.25

化驗

~90% (HPLC)

運輸包裝

wet ice

儲存溫度

−20°C

SMILES 字串

OC(=O)CN(CC(Cc1ccc(cc1)N=C=S)N(CC(O)=O)CC(O)=O)CC(O)=O

InChI

1S/C18H21N3O8S/c22-15(23)7-20(8-16(24)25)6-14(21(9-17(26)27)10-18(28)29)5-12-1-3-13(4-2-12)19-11-30/h1-4,14H,5-10H2,(H,22,23)(H,24,25)(H,26,27)(H,28,29)

InChI 密鑰

VHMWJVAFPCGUTJ-UHFFFAOYSA-N

應用

异硫氰苄基-EDTA 是一种用于生物共轭化学的双功能螯合剂,用于标记含伯胺的分子和蛋白质,优先标记其 N 端。

其他說明

胺反应性探针,可用于抗体螯合物标记

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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T M Rana et al.
Bioconjugate chemistry, 1(5), 357-362 (1990-09-01)
Conjugates of monoclonal antibodies with drugs, toxins, radionuclides, and other agents are in widespread use in therapeutic trials and as clinical research tools. The characterization of these immunoconjugates generally does not include determining the individual sites at which such agents
S V Deshpande et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 31(2), 218-224 (1990-02-01)
The metabolism of radiolabeled antibodies is important for radioimmunoimaging and therapy. The loss of indium-111 (111In) from the chelate can pose problems in imaging and increases the radiation dose to normal tissues. We have evaluated the loss in vivo of
K Shah et al.
Bioconjugate chemistry, 7(3), 283-289 (1996-05-01)
The synthesis of a C-5 modified uridine phosphoramidite which contains a primary amino group protected with Fmoc is described. During cleavage and deprotection of chemically synthesized RNA, the Fmoc protecting group is removed to yield a free amino group at
Z Yao et al.
Nuclear medicine and biology, 22(2), 199-203 (1995-02-01)
Tn antigen is a glycosylated tumor associated antigen and a murine monoclonal antibody, MLS128, has been identified to react with it. The potential of MLS128 for the radioimmunoimaging of colorectal cancer was studied. MLS128 was labeled with radioiodine by the

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