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Sigma-Aldrich

钙黄绿素-AM

Small Package (20 X 50 μg ), ≥95.0% (HPLC)

同義詞:

荧光素氨羧络合试剂, 钙黄绿素四乙酰氧基 O,O′-二乙酸酯, Calcein O,O′-diacetate tetrakis(acetoxymethyl) ester

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About This Item

經驗公式（希爾表示法）:
C46H46N2O23
CAS號碼:
148504-34-1
分子量：:
994.86
MDL號碼:
MFCD05861516
分類程式碼代碼:
12171500
PubChem物質ID:
329758218
NACRES:
NA.32

化驗

≥95.0% (HPLC)

螢光

λex 496 nm; λem 516 nm±5 nm in 0.1 M Tris pH 8.0, esterase; Ca2+

儲存溫度

−20°C

SMILES 字串

CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)Cc1c(OC(C)=O)ccc2c1Oc3c(CN(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)c(OC(C)=O)ccc3C24OC(=O)c5ccccc45

InChI

1S/C46H46N2O23/c1-25(49)60-21-64-39(55)17-47(18-40(56)65-22-61-26(2)50)15-32-37(68-29(5)53)13-11-35-43(32)70-44-33(16-48(19-41(57)66-23-62-27(3)51)20-42(58)67-24-63-28(4)52)38(69-30(6)54)14-12-36(44)46(35)34-10-8-7-9-31(34)45(59)71-46/h7-14H,15-24H2,1-6H3

InChI 密鑰

XKFSBWQWNMZWFA-UHFFFAOYSA-N

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相關類別

一般說明

钙黄绿素-AM，也称钙黄绿素-乙酰甲酯，是一种不发射荧光的分子，在细胞内酯酶的作用下会转化为阴离子荧光形式。在实验过程中它可以使黏附细胞连续成像。 钙黄绿素-AM是一种必不可少的染料，可在保持细胞膜完整的情况下将钙黄绿素引入活细胞。 钙黄绿素-AM中发射荧光的部分位于细胞间隙，在以酯酶依赖型关系在细胞中捕获，之后显示出细胞中的细胞毒性活性。

應用

钙黄绿素-AM是一种细胞活力染料，也可作为多药外排性转运体（multidrug efflux transporter）的中性底物。在癌症研究中，它可用作多药耐药蛋白MRP的中性底物。 用于测定人红细胞活力和老化的荧光测试法是以钙黄绿素-AM为探针。
钙黄绿素的非荧光细胞渗透衍生物，水解后发出荧光。 用作多药耐药蛋白MRP的中性底物；用于肿瘤研究。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

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Chembiochem : a European journal of chemical biology, 15(10), 1487-1494 (2014-06-04)
Aquaporins (AQPs) are membrane water/glycerol channels that are involved in many physiological functions. Aquaporin-based modulators are predicted to have potential utility in the treatment of several diseases, as well as chemical tools to assess AQPs function in biological systems. We
Bao-Ling Du et al.
Journal of biomedical materials research. Part A, 103(4), 1533-1545 (2014-07-22)
Biological materials combined with genetically-modified neural stem cells (NSCs) are candidate therapy targeting spinal cord injury (SCI). Based on our previous studies, here we performed gelatin sponge (GS) scaffold seeded with neurotrophin-3 (NT-3) and its receptor TrkC gene modifying NSCs
Johan van der Stok et al.
Tissue engineering. Part A, 21(9-10), 1495-1506 (2015-01-30)
A promising bone graft substitute is porous titanium. Porous titanium, produced by selective laser melting (SLM), can be made as a completely open porous and load-bearing scaffold that facilitates bone regeneration through osteoconduction. In this study, the bone regenerative capacity
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International journal of pharmaceutics, 485(1-2), 31-40 (2015-03-10)
Systemic administration of bisphosphonates, e.g. sodium alendronate (Aln) is characterized by extremely low bioavailability and high toxicity. To omit aforementioned drawbacks an injectable system for the intra-bone delivery of Aln based on Aln-loaded nanoparticles (NPs-Aln) suspended in a hydrogel matrix
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