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Merck
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重要文件

50838

Sigma-Aldrich

R)-甲羟戊酸 锂盐

≥93.0% (qNMR)

同義詞:

R-MVA-Li, (R)-3,5-二羟基-3-甲基戊酸锂

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About This Item

經驗公式(希爾表示法):
C6H11LiO4
CAS號碼:
分子量::
154.09
MDL號碼:
分類程式碼代碼:
12352106
PubChem物質ID:
NACRES:
NA.25

化驗

≥93.0% (qNMR)

光學活性

[α]/D -26±3°, c = 0.1 in 0.1 M HCl (16 h)

儲存溫度

2-8°C

SMILES 字串

[Li+].C[C@@](O)(CCO)CC([O-])=O

InChI

1S/C6H12O4.Li/c1-6(10,2-3-7)4-5(8)9;/h7,10H,2-4H2,1H3,(H,8,9);/q;+1/p-1/t6-;/m1./s1

InChI 密鑰

PVWNXFFXFNEHDZ-FYZOBXCZSA-M

應用

甲羟戊酸可用作分离或检测甲羟戊酸试验中的参考材料。甲羟戊酸是异戊烯焦磷酸(IPP)和甲羟戊酸途径的前体,它可以引导类异戊二烯生物的合成。甲羟戊酸可用作鉴定和表征甲羟戊酸激酶的底物。

生化/生理作用

甲羟戊酸是甲羟戊酸途径中的中间体,产生萜烯和类固醇。该功能提供治疗选择为常染色体隐性遗传甲羟戊酸尿症(一种胆固醇和非甾醇异戊二烯生物合成的先天性错误)患者的代谢紊乱 、R-甲羟戊酸累积提供了治疗选项

包裝

无底玻璃瓶。内含物装在插入的融合锥内。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Discovery and chemistry of mevalonic acid.
Wagner, A. F. and Folkers, K.
Advances in Enzymology and Related Areas of Molecular Biology, 23, 471-483 (1961)
S M Houten et al.
Cellular and molecular life sciences : CMLS, 60(6), 1118-1134 (2003-07-16)
Mevalonate kinase (MK) is an essential enzyme in the isoprenoid biosynthesis pathway which produces numerous biomolecules (isoprenoids) involved in a variety of cellular processes. The indispensability of MK and isoprenoid biosynthesis for human health is demonstrated by the identification of
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Mevalonic aciduria (MVA) and hyperimmunoglobulinemia D syndrome (HIDS) represent the two ends of a clinical spectrum of disease caused by deficiency of mevalonate kinase (MVK), the first committed enzyme of cholesterol biosynthesis. At least 30 patients with MVA and 180
G Hoffmann et al.
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A two-year-old boy presented with severe failure to thrive, developmental delay, anemia, hepatosplenomegaly, central cataracts, and dysmorphic features. Quantitative analyses of urinary organic acids revealed massive excretion of mevalonic acid, a metabolic precursor of cholesterol and nonsterol isoprenes: 46,000 to

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