484R-1

PRAME (EP461) Rabbit Monoclonal Primary Antibody

• 同義詞: Preferentially-expressed Antigen in Melanoma
• 分類程式碼代碼: 12352203

屬性

• 生物源: rabbit
• 品質等級: 100; 500
• 共軛: unconjugated
• 抗體表格: culture supernatant
• 抗體產品種類: primary antibodies
• 無性繁殖: EP461, monoclonal
• 描述: For In Vitro Diagnostic Use in Select Regions
• 形狀: buffered aqueous solution
• 物種活性: human
• 包裝: vial of 0.1 mL concentrate (484R-14); vial of 0.1 mL concentrate Research Use Only (484R-14-RUO); vial of 0.5 mL concentrate (484R-15); vial of 1.0 mL concentrate (484R-16); vial of 1.0 mL concentrate Research Use Only (484R-16-RUO); vial of 1.0 mL pre-dilute Research Use Only (484R-17-RUO); vial of 1.0 mL pre-dilute ready-to-use (484R-17); vial of 25.0 mL pre-dilute ready-to-use Research Use Only (484R-10-RUO); vial of 25.0 mL pre-dilute ready-to-use (484R-10); vial of 7.0 mL pre-dilute ready-to-use (484R-18); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (484R-18-RUO)
• 技術: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)
• 同型: IgG
• 控制: melanoma
• 運輸包裝: wet ice
• 儲存溫度: 2-8°C
• 視覺化: nuclear

描述

一般說明

PRAME (PReferentially-expressed Antigen in MElanoma) is a gene encoded on the 22q11-22 chromosomal sequence and encodes a 509 amino acid residue protein.¹ PRAME is a melanoma antigen that is preferentially expressed in tumors and is recognized by cytotoxic T lymphocytes.^2,3 PRAME can be used to distinguish between malignant melanoma cells and nevus cells,⁴ and therefore may be useful for diagnostic purposes to support a suspected case of melanoma. PRAME is considered a cancer-testis antigen (CTA)⁵ and is not strongly expressed in most other normal tissues. PRAME is positively expressed in about half of uveal melanomas,⁶ and the majority of mucosal melanomas.⁷

品質

• United States - IVD
• Canada - RUO
• European Union - IVD
• Japan - RUO

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and < 0.1% Sodium Azide.

準備報告

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其他說明

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安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable