推薦產品
生物源
rabbit
品質等級
100
500
共軛
unconjugated
抗體表格
culture supernatant
抗體產品種類
primary antibodies
無性繁殖
SP49, monoclonal
描述
For In Vitro Diagnostic Use in Select Regions (See Chart)
形狀
buffered aqueous solution
物種活性
human
包裝
vial of 0.1 mL concentrate (394R-14)
vial of 0.5 mL concentrate (394R-15)
bottle of 1.0 mL predilute (394R-17)
vial of 1.0 mL concentrate (394R-16)
bottle of 7.0 mL predilute (394R-18)
製造商／商標名
Cell Marque™
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
同型
IgG
控制
cervical intraepithelial neoplasia – high grade, tonsil
運輸包裝
wet ice
儲存溫度
2-8°C
視覺化
cytoplasmic
基因資訊
human ... STMN1(3925)
一般說明
The distinction between high grade cervical intraepithelial neoplasia (CIN2/3) from low grade cervical intraepithelial neoplasia (CIN1) is clinically significant with treatment recommendations linked specificallyto risk of cancer or CIN3 outcome. CIN1 will progress into invasive carcinoma in <1% of cases and is typically managed with Papanicolaou smear follow-up, whereas CIN2/3 has a 5% to 20% risk of progression1 and is usually treated with an excisional procedure (loop electrosurgical excision procedure or cone biopsy).1 Stathmin, also referred to as Stathmin-1 and oncoprotein18, is a ubiquitous microtubule-destabilizing protein shown to be important during mitosis and has been implicated as a regulator of cell motility and migration.
Recent studies show anti-stathmin is positive in 24/82 (29%) CINs with differential expression based on the grade of the lesion as 5/56 (9%) CIN1, 5/11 (45%) CIN2, and 14/15 (93%) CIN3; whereas, anti-p16 staining of the same cases was immuno-reactive in 66/83 (80%) CINs, including 40/56 (71%) CIN1, 11/11 (100%) CIN2, and 15/16 (94%) CIN3. Anti-stathmin shows similar sensitivity for CIN3 to anti-p16 (93% vs 94%) although it drops off for CIN2 (73% vs 96%). The specificity of anti-stathmin for both CIN2/3 (94%) and CIN3 (89%) is higher than that of anti-p16 (44% and 39%, respectively). Anti-Stathmin stains basal layer of normal benign ectocervix. A well-oriented fragment of cervix tissue would increase the accuracy of diagnosis. In conclusion, based on recent studies, anti-stathmin has a higher specificity relative to anti-p16; therefore, anti-stathmin has major potential as a diagnostic marker in CIN classification over anti-p16.
Recent studies show anti-stathmin is positive in 24/82 (29%) CINs with differential expression based on the grade of the lesion as 5/56 (9%) CIN1, 5/11 (45%) CIN2, and 14/15 (93%) CIN3; whereas, anti-p16 staining of the same cases was immuno-reactive in 66/83 (80%) CINs, including 40/56 (71%) CIN1, 11/11 (100%) CIN2, and 15/16 (94%) CIN3. Anti-stathmin shows similar sensitivity for CIN3 to anti-p16 (93% vs 94%) although it drops off for CIN2 (73% vs 96%). The specificity of anti-stathmin for both CIN2/3 (94%) and CIN3 (89%) is higher than that of anti-p16 (44% and 39%, respectively). Anti-Stathmin stains basal layer of normal benign ectocervix. A well-oriented fragment of cervix tissue would increase the accuracy of diagnosis. In conclusion, based on recent studies, anti-stathmin has a higher specificity relative to anti-p16; therefore, anti-stathmin has major potential as a diagnostic marker in CIN classification over anti-p16.
品質
 IVD |  IVD |  IVD |  RUO |
聯結
Stathmin Positive Control Slides, Product No. 394S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外觀
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
準備報告
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
其他說明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律資訊
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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Patients with fatal gunshot wounds (GSWs) to the head often have poor outcomes but are ideal candidates for organ donation. The purpose of this study was to evaluate the effects of aggressive management on organ donation in patient with fatal
K J Syrjänen
European journal of obstetrics, gynecology, and reproductive biology, 65(1), 45-53 (1996-03-01)
Because of the fact that any meaningful classification should bear a close relationship to the biological behavior of the lesions, the usefulness of all new classifications of cervical precancer lesions can only be established by well controlled prospective follow-up studies.
Barbara Belletti et al.
Expert opinion on therapeutic targets, 15(11), 1249-1266 (2011-10-08)
Stathmin is a microtubule-destabilizing phosphoprotein, firstly identified as the downstream target of many signal transduction pathways. Several studies then indicated that stathmin is overexpressed in many types of human malignancies, thus deserving the name of Oncoprotein 18 (Op18). At molecular
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