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Key Documents

343R-1

Sigma-Aldrich

TTF-1 (EP229) Rabbit Monoclonal Primary Antibody

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

100
500

共軛

unconjugated

抗體表格

culture supernatant

抗體產品種類

primary antibodies

無性繁殖

EP229, monoclonal

描述

(For In Vitro Diagnostic Use in Select Regions (See Chart))

形狀

buffered aqueous solution

物種活性

human

包裝

vial of 0.1 mL concentrate (343R-14)
vial of 0.5 mL concentrate (343R-15)
bottle of 1.0 mL predilute (343R-17)
vial of 1.0 mL concentrate (343R-16)
bottle of 7.0 mL predilute (343R-18)

製造商/商標名

Cell Marque

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200

同型

IgG

控制

lung adenocarcinoma

運輸包裝

wet ice

儲存溫度

2-8°C

視覺化

nuclear

基因資訊

human ... A1CF(29974)

一般說明

Anti-TTF-1 (Thyroid Transcription Factor 1) is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the organs rather than thyroid1-2, germ cell tumors3, and malignant mesothelioma.4-5 It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.6 TTF-1 labeling is also seen in thyroid and thyroid-derived tumors.7 TTF-1 immunostaining is useful in the differentiation between pulmonary and nonpulmonary origin of adenocarcinomas in malignant effusions.8 TTF-1 staining is very reliable in discerning whether a brain metastasis has arisen from a pulmonary or nonpulmonary site, particularly when dealing with adenocarcinomas and large-cell carcinomas.9

品質


IVD

IVD

IVD

RUO

聯結

TTF-1 Positive Control Slides, Product No. 343S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

準備報告

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

其他說明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律資訊

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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A R Altman et al.
Gastroenterology, 77(6), 1211-1216 (1979-12-01)
A family was studied in which three middle-aged siblings had unexplained cirrhosis and steatosis. Five of nine additional family members had abnormalities of liver function. Liver biopsy in those 5 revealed steatosis in 3, steatosis and fibrosis in 1, and
P A Bejarano et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 9(4), 445-452 (1996-04-01)
Antibodies to the pulmonary epithelial cell-specific proteins surfactant proteins A and B (SP-A and SP-B) and to thyroid transcription factor-1 (TTF-1), a homeodomain nuclear transcription protein, were used as immunohistochemical markers to asses their ability to distinguish primary pulmonary non-small
C Di Loreto et al.
Cancer letters, 124(1), 73-78 (1998-03-21)
TTF-1 is a tissue-specific transcription factor expressed in the epithelial cells of thyroid and lung. This study investigates the immunohistochemical expression of TTF-1 in pleural malignant mesotheliomas (MM) and adenocarcinomas (AC) of the lung, respectively. For this purpose, 33 biopsy
R Katoh et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 13(5), 570-576 (2000-05-29)
Thyroid transcription factor-1 (TTF-1) has been known to regulate the transcriptional activity of thyroid-specific genes. We examined the expression of TTF-1 in non-neoplastic and neoplastic thyroid tissues. By immunohistochemistry, the nuclei of normal and hyperplastic follicular cells strongly reacted with
K Y Jang et al.
Analytical and quantitative cytology and histology, 23(6), 400-404 (2002-01-05)
To estimate the utility of thyroid transcription factor-1 (TTF-1) and the combined cytokeratin 7 (CK7) and 20 (CK20) immunoprofile as a marker for identifying the primary site of metastatic adenocarcinoma in effusions of the serous cavity. Formalin-fixed, paraffin-embedded cell block

文章

Colorectal cancer is the third most common cancer in both men and women. An estimated 136,000 cases of colorectal cancer are expected to occur in 2016.

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