SMB00963

Desethylchloroquine

≥95% (HPLC)

• 同義詞: 7-Chloro-4-{[4-(ethylamino)-1-methylbutyl]amino}quinoline, 4-[[1-Methyl-4-((ethylamino)butyl]amino)]-7-chloroquinoline, 7-Chloro-4-(4-N-ethylamino-1-methylbutylamino)quinoline, N-Desethyl chloroquine, N-Desethylchloroquine, N⁴-(7-Chloro-4-quinolinyl)-N¹-ethyl-1,4-pentanediamine, Monodeethylchloroquine, Monodesethylchloroqu​ine
• 經驗公式（希爾表示法）: C₁₆H₂₂ClN₃
• CAS號碼: 1476-52-4
• 分子量：: 291.82
• MDL號碼: MFCD00871808
• 分類程式碼代碼: 41116107
• NACRES: NA.77

屬性

• 生物源: synthetic
• 品質等級: 200
• 等級: research grade
• 化驗: ≥95% (HPLC)
• 形狀: powder or crystals
• 技術: HPLC: suitable
• 顏色: white to off-white
• 運輸包裝: wet ice
• 儲存溫度: 2-8°C
• SMILES 字串: ClC(C=C1)=CC2=C1C(NC(CCCNCC)C)=CC=N2
• InChI: 1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20)
• InChI 密鑰: MCYUUUTUAAGOOT-UHFFFAOYSA-N

描述

一般說明

Desethylchloroquine is a metabolite of hydroxychloroquine and chloroquine. Hydroxychloroquine and chloroquine have antimalarial properties and are used as a therapeutic for rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumatic diseases. They have also been in the spotlight due to their activity on patients with COVID-19, the disease caused by the SARS-CoV-2 virus. Hydroxychloroquine and chloroquine interfere with lysosomal activity and autophagy, interact with membrane stability and alter signalling pathways and transcriptional activity, which can result in modulation of cytokine production. Their mode of action is still emerging and their metabolism is of great interest.

應用

Application: Metabolomics research

其他說明

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安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable