PHR1625

卢非酰胺

Pharmaceutical Secondary Standard; Certified Reference Material

• 同義詞: Rufinamide, 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-Triazole-4-carboxamide
• 經驗公式（希爾表示法）: C₁₀H₈F₂N₄O
• CAS號碼: 106308-44-5
• 分子量：: 238.19
• MDL號碼: MFCD00865314
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329823517
• NACRES: NA.24

屬性

• 等級: certified reference material; pharmaceutical secondary standard
• 品質等級: 300
• agency: traceable to USP 1606401
• API 家族: rufinamide
• CofA: current certificate can be downloaded
• 包裝: pkg of 500 mg
• 技術: HPLC: suitable; gas chromatography (GC): suitable
• 應用: pharmaceutical (small molecule)
• 格式: neat
• 儲存溫度: 2-30°C
• SMILES 字串: NC(=O)c1cn(Cc2c(F)cccc2F)nn1
• InChI: 1S/C10H8F2N4O/c11-7-2-1-3-8(12)6(7)4-16-5-9(10(13)17)14-15-16/h1-3,5H,4H2,(H2,13,17)
• InChI 密鑰: POGQSBRIGCQNEG-UHFFFAOYSA-N
• 基因資訊: human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

描述

一般說明

Rufinamide is an antiepileptic drug, used as an adjunctive for the treatment of seizures associated with Lennox−Gastaut syndrome. Its mode of action involves prolonging the refractory period of voltage-dependent sodium channels via stabilization of the sodium channel inactive state, thus effectively keeping the ion channels closed.

應用

Rufinamide may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化／生理作用

Broad-spectrum anticonvulsant.

診斷意義

Effective therapy for partial seizures in adults and childhood seizures in Lennox-Gastaut syndrome.

分析報告

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他說明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

腳註

To see an example of a Certificate of Analysis for this material enter LRAA5294 in the slot below. This is an example certificate only and may not be the lot that you receive.

安全資訊

• 象形圖: GHS08,GHS07
• 訊號詞: Warning
• 危險聲明: H336,H351,H361fd
• 防範說明: P202 - P261 - P271 - P280 - P304 + P340 + P312 - P308 + P313
• 危險分類: Carc. 2 - Repr. 2 - STOT SE 3
• 標靶器官: Central nervous system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable