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重要文件

P0550000

奋乃静

European Pharmacopoeia (EP) Reference Standard

同義詞:

4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol

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About This Item

經驗公式(希爾表示法):
C21H26ClN3OS
CAS號碼:
分子量::
403.97
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

perphenazine

製造商/商標名

EDQM

應用

pharmaceutical (small molecule)

形式

neat

儲存溫度

2-8°C

SMILES 字串

ClC(C=C1)=CC2=C1SC3=CC=CC=C3N2CCCN4CCN(CCO)CC4

InChI

1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2

InChI 密鑰

RGCVKNLCSQQDEP-UHFFFAOYSA-N

基因資訊

human ... DRD2(1813)

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一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Perphenazine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro.

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral - Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

Lot/Batch Number

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B Hartung et al.
The Cochrane database of systematic reviews, (1)(1), CD003443-CD003443 (2005-01-28)
Perphenazine is an old phenothiazine antipsychotic with a potency similar to haloperidol. It has been used for many years and is popular in the northern European countries and Japan. To examine the clinical effects and safety of perphenazine for those
Alexander Schnabel et al.
European journal of anaesthesiology, 27(12), 1044-1051 (2010-08-27)
despite the introduction of newer antiemetics in the prevention of postoperative nausea and vomiting (PONV), perphenazine is recommended in current guidelines, as the concept of multimodal management of PONV in high-risk patients requires more than two drugs to be combined.
Disposition of the neuroleptics perphenazine, zuclopenthixol, and haloperidol cosegregates with polymorphic debrisoquine hydroxylation.
L Bertilsson et al.
Psychopharmacology series, 10, 230-237 (1993-01-01)
A David et al.
The Cochrane database of systematic reviews, (3)(3), CD001717-CD001717 (2005-07-22)
Antipsychotic drugs are usually given orally but compliance with medication given by this route may be difficult to quantify. The development of depot injections in the 1960s gave rise to extensive use of depots as a means of long-term maintenance
Perphenazine serum levels in patients on standard doses.
F Haffner
Psychopharmacology series, 7, 280-283 (1989-01-01)

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