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重要文件

P0270000

罂粟碱 盐酸盐

European Pharmacopoeia (EP) Reference Standard

同義詞:

6,7-Dimethoxy-1-veratrylisoquinoline hydrochloride

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About This Item

經驗公式(希爾表示法):
C20H21NO4 · HCl
CAS號碼:
分子量::
375.85
Beilstein:
3921435
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

papaverine

製造商/商標名

EDQM

應用

pharmaceutical (small molecule)

形式

neat

SMILES 字串

COC1=C(OC)C=C(C(CC2=CC(OC)=C(OC)C=C2)=NC=C3)C3=C1.Cl

InChI

1S/C20H21NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-8,10-12H,9H2,1-4H3;1H

InChI 密鑰

UOTMYNBWXDUBNX-UHFFFAOYSA-N

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一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Papaverine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

Smooth muscle relaxant and cerebral vasodilator; phosphodiesterase inhibitor.

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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Bojidarka Ivanov et al.
Natural product communications, 7(5), 581-586 (2012-07-18)
The electronic structures, optical properties and molecular structures of a series of isoquinoline alkaloids resulting in the formation of papaverine, through a proposed biosynthetic pathway via S(+)-reticuline were elucidated. The mechanism of papaverine synthesis was studied by electronic absorption, diffuse
J M Mathis et al.
Neuroradiology, 39(2), 90-98 (1997-02-01)
Intra-arterial infusion of papaverine hydrochloride for subarachnoid hemorrhage-induced cerebral vasospasm has become an adjunctive endovascular therapy along with cerebral angioplasty. Our knowledge concerning the mechanism of action, method of administration and potential side effects of this therapeutic alternative are reviewed.
Isabel Desgagné-Penix et al.
The Plant journal : for cell and molecular biology, 72(2), 331-344 (2012-06-26)
Papaverine, a major benzylisoquinoline alkaloid in opium poppy (Papaver somniferum), is used as a vasodilator and antispasmodic. Conversion of the initial intermediate (S)-norcoclaurine to papaverine involves 3'-hydroxylation, four O-methylations and dehydrogenation. However, our understanding of papaverine biosynthesis remains controversial more
Y Yazir et al.
International journal of impotence research, 24(5), 185-190 (2012-05-11)
Epidemiological evidence showed that chronic ethanol consumption is a major risk factor in the development of impotence. The present study investigated the effects of carbachol-, electrical field stimulation (EFS)-, sodium nitroprusside (SNP)- and papaverine-induced relaxant responses in the isolated corpus
Doreen Schmidl et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 251(2), 515-520 (2012-12-04)
To investigate the effect of orally administered moxaverine (Kollateral forte®) on ocular blood flow in young healthy subjects. Sixteen healthy subjects (eight male/eight female) aged between 20 and 32 years were included in this placebo-controlled, double-masked, two-way crossover study. Volunteers

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