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Merck
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重要文件

A5000

Sigma-Aldrich

对乙酰氨基酚

meets USP testing specifications, 98.0-102.0%, powder

同義詞:

4′-羟基乙酰苯胺, 4-乙酰氨基酚, N-(4-羟基苯基)乙酰胺, N-乙酰基-4-氨基苯酚, APAP, 扑热息痛

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About This Item

線性公式:
CH3CONHC6H4OH
CAS號碼:
分子量::
151.16
Beilstein:
2208089
MDL號碼:
分類程式碼代碼:
12352111
PubChem物質ID:
NACRES:
NA.25

agency

USP/NF
meets USP testing specifications

品質等級

化驗

98.0-102.0%

形狀

powder

mp

168-172 °C (lit.)

溶解度

DMSO: 5 M
ethanol: 50 mg/mL
H2O: very slightly soluble

應用

pharmaceutical (small molecule)

SMILES 字串

CC(=O)Nc1ccc(O)cc1

InChI

1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

InChI 密鑰

RZVAJINKPMORJF-UHFFFAOYSA-N

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應用

镇痛剂。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

364.3 °F - Pensky-Martens closed cup

閃點(°C)

184.6 °C - Pensky-Martens closed cup

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

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Mohammad A Rahman et al.
Scientific reports, 9(1), 6571-6571 (2019-04-27)
Cellular CYP2E1 is well-known to mediate alcohol- (ALC) and acetaminophen- (APAP) induced toxicity in hepatic and extra-hepatic cells. Although exosomes have been gaining importance in understanding mechanism of intra- and inter-cellular communication, the functional role of drug metabolizing cytochrome P450
S M de Morais et al.
Gastroenterology, 102(2), 577-586 (1992-02-01)
Gilbert's syndrome occurs in 5%-7% of the human population and is caused by an inherited deficiency in the glucuronidation of endogenous bilirubin, resulting in its accumulation and jaundice. The authors of the present study have previously shown that rats with
Edward Munsterhjelm et al.
Anesthesiology, 103(4), 712-717 (2005-09-30)
Acetaminophen (paracetamol) is widely used for postoperative analgesia. Its mechanism of action is inhibition of prostaglandin synthesis in the central nervous system, and acetaminophen is traditionally not considered to influence platelet function. The authors studied the dose-dependent inhibition of platelet
Mitchell R McGill et al.
Pharmaceutical research, 30(9), 2174-2187 (2013-03-07)
Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver. The first studies of APAP metabolism and activation were published more than 40 years ago.
Garry G Graham et al.
Drug safety, 28(3), 227-240 (2005-03-01)
The excellent tolerability of therapeutic doses of paracetamol (acetaminophen) is a major factor in the very wide use of the drug. The major problem in the use of paracetamol is its hepatotoxicity after an overdose. Hepatotoxicity has also been reported

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