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94873

Supelco

4-羟基他莫西芬

(E) and (Z) isomers (50:50), analytical standard

同義詞:

4-(1-[4-(二甲基氨基乙氧基)苯基]-2-苯基-1-丁烯)苯酚, 4-OHT, 顺/反-4-羟基三苯氧胺

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About This Item

經驗公式(希爾表示法):
C26H29NO2
CAS號碼:
分子量::
387.51
分類程式碼代碼:
41116107
NACRES:
NA.24

等級

analytical standard

品質等級

化驗

≥97.5% (HPLC)

儲存期限

limited shelf life, expiry date on the label

技術

HPLC: suitable
gas chromatography (GC): suitable

雜質

≤5.0% water

應用

forensics and toxicology
pharmaceutical (small molecule)

格式

neat

SMILES 字串

CC\C(c1ccccc1)=C(/c2ccc(O)cc2)c3ccc(OCCN(C)C)cc3.CC\C(c4ccccc4)=C(\c5ccc(O)cc5)c6ccc(OCCN(C)C)cc6

InChI

1S/2C26H29NO2/c2*1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h2*5-17,28H,4,18-19H2,1-3H3/b26-25+;26-25-

InChI 密鑰

ZJLDABGSDWXVGE-BDSXMVAQSA-N

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一般說明

4-羟基他莫昔芬是第一代选择性雌激素受体调节剂(SERM),在乳腺癌细胞中起拮抗剂作用,但在子宫和骨骼中可表现出雌激素样活性。

應用

4-羟基他莫昔芬可用作参考标准品,通过高效液相色谱法(HPLC)和荧光检测测定血浆样品中的4-羟基他莫昔芬。
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生化/生理作用

化疗药物他莫昔芬的代谢物,表现出比母体药物更有效的雌激素激动剂/拮抗剂活性。也具有脂质过氧化的膜内抑制剂的活性。

象形圖

Health hazardExclamation mark

訊號詞

Warning

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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