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Merck
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重要文件

46148

Supelco

肾上腺酮

VETRANAL®, analytical standard

同義詞:

11β,21-二羟丙酮-4-孕烯-3,20-二酮, 11β,21-二羟基黄体酮, 4-孕烯-11β,21-二醇-3,20-二酮, Kendall化合物B, Reichstein物质H

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About This Item

經驗公式(希爾表示法):
C21H30O4
CAS號碼:
分子量::
346.46
Beilstein:
2339601
EC號碼:
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

analytical standard

品質等級

產品線

VETRANAL®

化驗

≥98% (HPLC)

儲存期限

limited shelf life, expiry date on the label

技術

HPLC: suitable
gas chromatography (GC): suitable

mp

179-183 °C (lit.)

應用

pharmaceutical (small molecule)

形式

neat

SMILES 字串

C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO

InChI

1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

InChI 密鑰

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

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一般說明

Corticosterone is one of the principal steroids secreted by the rat adrenal gland and found in rat plasma.

應用

Corticosterone may be used as a reference standard in the determination of corticosterone in plasma samples using high-performance liquid chromatography (HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

法律資訊

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Determination of plasma corticosterone using high-performance liquid chromatography.
Woodward HJC and Emery WP
Journal of Chromatography. B, Biomedical Sciences and Applications, 419(2), 280-284 (1987)
The estimation of small amounts of corticosterone in rat plasma.
Zenker N and Bernstein ED
The Journal of Biological Chemistry, 231(2), 695-701 (1958)
Kirsten R Jacobsen et al.
Comparative medicine, 63(2), 105-113 (2013-04-16)
Laboratory mice constitute an extensively used model to study the pathologic and functional outcomes of cerebral ischemic stroke. The middle cerebral artery occlusion (MCAO) model requires surgical intervention, which potentially can result in postsurgical pain and stress. In the present
Selective retention of corticosterone by limbic structures in rat brain.
McEwen SB, et al.
Nature, 220(5170), 911-911 (1968)
Damiano Azzinnari et al.
Neuropharmacology, 85, 328-341 (2014-06-08)
In neuropsychiatry, animal studies demonstrating causal effects of environmental manipulations relevant to human aetiology on behaviours relevant to human psychopathologies are valuable. Such valid models can improve understanding of aetio-pathophysiology and preclinical discovery and development of new treatments. In depression

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