MABS1198

Anti-SPINK1 Antibody, clone 4D11.1

clone 4D11.1, from mouse

• 同義詞: Serine protease inhibitor Kazal-type 1, Pancreatic secretory trypsin inhibitor, TATI, Tumor-associated trypsin inhibitor
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 4D11.1, monoclonal
• 物種活性: human
• 技術: immunohistochemistry: suitable (paraffin); western blot: suitable
• 同型: IgG1κ
• NCBI登錄號: NP_003113
• UniProt登錄號: P00995
• 運輸包裝: ambient
• 目標翻譯後修改: unmodified
• 基因資訊: human ... SPINK1(6690)

描述

一般說明

Serine protease inhibitor Kazal-type 1 (UniProt P00995; also known as Pancreatic secretory trypsin inhibitor, TATI, Tumor-associated trypsin inhibitor) is encoded by the SPINK1 (also known as PCTT, PSTI, TCP) gene (Gene ID 6690) in human. Serine protease inhibitor Kazal-type 1 encoded by the human SPINK1 gene functions as an acute-phase protein (APP) in the pancreas. Produced initially in a 79-a.a. proform, the signal peptide (a.a. 1-23) is removed posttranslationally to yield the 56-a.a. (a.a. 24-79) mature protein. SPINK1 protein blocks premature activation of trypsinogen (inactive form of trypsin), thereby ensuring the integrity of acinar cells to prevent auto-digestion of the pancreas. SPINK1 is also reported to play a role in tissue repair, apoptosis, reproduction, and behave as a growth factor in other human organs. In addition, SPINK1 protein is known as tumor-associated trypsin inhibitor or TATI and current research activities are focused on the association of various cancers to deregulated SPINK1 activity.

特異性

Expected to react with both pro- and mature human SPINK1.

免疫原

GST-tagged recombinant human SPINK1.

應用

Anti-SPINK1, clone 4D11.1, Cat. No. MABS1198, is a highly specific mouse monoclonal antibody that targets SPINK1 and has been tested in Immunohistochemistry and Western Blotting.

Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected SPINK1 in human pancreas tissue sections.

Research Category
Signaling

品質

Evaluated by Western Blotting of SPINK1 GST fusion protein.

Western Blotting Analysis (WB): A 1:5000 dilution of this antibody detected 50 ng of recombinant human SPINK1 GST fusion protein.

標靶描述

6.247/8.507 kDa (mature/pro-form) calculated. Uncharacterized band(s) may appear in some lysates.

外觀

Protein G purified.

Format: Purified

Purified mouse monoclonal IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4) 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable