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Key Documents

NCI-H322 Cell Line human

95111734, human lung (cervical node metastasis), Not specified

同義詞:

H322 Cells, NCI-322 Cells, NCI-H322T Cells

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About This Item

分類程式碼代碼:
41106514

product name

NCI-H322 Cell Line human, 95111734

生物源

human lung (cervical node metastasis)

描述

Human Caucasian bronchioalveolar carcinoma

增長模式

Adherent

染色體組型

Not specified

形態學

Not specified

產品

Not specified

受體

Not specified

技術

cell culture | mammalian: suitable

相關疾病

metastasis

運輸包裝

dry ice

儲存溫度

−196°C

細胞系來源

Human Caucasian bronchioalveolar carcinoma

細胞系描述

NCI-H322 was derived in 1981 from a primary bronchioalveolar carcinoma of the lung from a 52 year old male taken prior to treatment. Ultrastructural studies of this non-small cell carcinoma cell line demonstrated the presence of cytoplasmic structures characteristic of Clara cells. NCI-H322 do not express UDP-glucuronosyltransferase, but are reported to express glutathione-S-transferase and phenol sulfotransferase. Expression of protein and RNA of SP-A, the major surfactant-associated protein was detected. The cells produce tumours in athymic mice.

應用

NCI-H322 has been used to study the preclinical antitumor efficacy of BAY 1129980, which is an anti-C4.4A (Ly6/PLAUR domain-containing protein 3 precursor-LYPD3) antibody–drug conjugate for the treatment of non–small cell lung cancer.
Test system for evaluating cytotoxicity and genotoxicity of chemicals to human lung

培養基

RPMI 1640 + 2mM Glutamine + 5-10% Foetal Bovine Serum (FBS).

例行更新培養

Split sub-confluent cultures (70-80%) 1:3 to 1:6 i.e. seeding at 1-3x10,000 cells/cm2 using 0.25% trypsin or trypsin/EDTA; 5% CO2; 37°C.

其他說明

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