MABS1195

Anti-SSH1 Antibody, clone 12C6.1

clone 12C6.1, from mouse

• 同義詞: Protein phosphatase Slingshot homolog 1, hSSH-1L, Slingshot homolog 1, SSH-1L, SSH-like protein 1
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: 12C6.1, monoclonal
• 物種活性: human
• 技術: western blot: suitable
• 同型: IgG2aκ
• NCBI登錄號: NP_061857
• UniProt登錄號: Q8WYL5
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... SSH1(54434)

描述

一般說明

Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16; EC 3.1.3.48; UniProt Q8WYL5; also known as hSSH-1L, Slingshot homolog 1, SSH-1L, SSH-like protein 1) is encoded by the SSH1 (also known as KIAA1298, SSH1L) gene (Gene ID 54434) in human. SSH1 is the founding member of the Slingshot family of protein phosphatases that function to destabilize the actin cytoskeleton by reversing cofilin Ser3 phosphorylation and thereby re-activating cofilin. Cofilin plays a central role in regulating actin filament turnover and actin cytoskeletal remodelling by severing and depolymerizing actin filaments. Cofilin activity is negatively regulated by LIM kinases-catalyzed Ser3 phosphorylation. The Slingshot family members include SSH-1L, SSH-2L, SSH-3L, and chronophin. The members differ in their subcellular distribution, F-actin-binding activity, and phosphatase activity, implying related but member-specific functions.

特異性

Expected to react with spliced isoform 1 (isoform L), isoform 2 (isoform S), isoform 4, and isoform 5, but not isoform 3 (isoform B) reported by UniProt (Q8WYL5).

免疫原

GST-tagged recombinant protein corresponding to an internal sequence of human SSH1.

應用

Anti-SSH1 Antibody, clone 12C6.1 is an antibody against SSH1 for use in Western Blotting.

品質

Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected SSH1 in 10 µg of HeLa cell lysate.

標靶描述

~150 kDa observed. 115.5 kDa (isoform 1), 77.43 kDa (isoform 2), 80.68 kDa (isoform 4), and 78.98 kDa (isoform 5) calculated.

外觀

Format: Purified

其他說明

Concentration: Please refer to lot specific datasheet.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable