MABN358

Anti-NB thymosin beta (TMSB15A Antibody), Clone 4A6.3

clone 4A6.3, from mouse

• 同義詞: Thymosin beta-15A, NB thymosin beta, Thymosin-like protein 8
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: 4A6.3, monoclonal
• 物種活性: human
• 技術: immunohistochemistry: suitable (paraffin)
• 同型: IgMκ
• NCBI登錄號: NP_068832
• UniProt登錄號: P0CG34
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... TMSB15A(11013)

描述

一般說明

TMSB15A protein is a key regulator of the cytoskeleton organization and polymerization, and it thus plays a role in cell migration, proliferation and cancer. TMSB15A does this because TMSB15A binds to and sequesters actin monomers and limits action polymerization. TMSB15A is differentially expressed in many tissues and cancer cell lines. Because of differential expression in certain cancers, for instance in triple negative breast cancer but not colon cancer, TMSB15A is being examined as a histochemical marker for measuring the effectiveness of cancer therapy on cancer. TMSB15A is also important in the nervous system and brain diseases. Notably, TMSB15A expression is increased upon brain stress and surprisingly TMSB15A localization differs depending upon the type of stress used and neuronal cell type. Because of its interaction with actin, TMSB15A is localized to the cytoplasm most of time, however, in the brain and when cells are placed under various stresses, TMSB15A can be translocated to the brain to perform yet unknown functions as well.

免疫原

KLH-conjugated linear peptide corresponding to Human TMSB15A.

應用

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TMSB15A in human thalamic and human brain cancer tissues.

This Anti-NB thymosin beta (TMSB15A Antibody), Clone 4A6.3 is validated for use in Immunohistochemistry (Paraffin) for the detection of NB thymosin beta (TMSB15A).

品質

Evaluated by Immunohistochemistry in human cerebral cortex tissue.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TMSB15A in human cerebral cortex tissue

標靶描述

5 kDa calculated

外觀

Format: Purified

其他說明

Concentration: Please refer to lot specific datasheet.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable