MABC1031

Anti-TNFSF13 (APRIL) Antibody, clone A3D8

clone A3D8, from hamster(Armenian)

• 同義詞: A proliferation-inducing ligand, APRIL, CD256, TALL-2
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.43
• 無性繁殖: A3D8, monoclonal
• application: FACS
• 物種活性: human, mouse
• 技術: flow cytometry: suitable

屬性

• 生物源: hamster (Armenian)
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: A3D8, monoclonal
• 物種活性: human, mouse
• 技術: flow cytometry: suitable
• 同型: IgG
• NCBI登錄號: NP_076006
• UniProt登錄號: Q9D777
• 運輸包裝: ambient
• 目標翻譯後修改: unmodified
• 基因資訊: mouse ... Tnfsf13(69583)

描述

一般說明

Tumor necrosis factor ligand superfamily member 13 (UniProt: Q9D777; also known as A proliferation-inducing ligand; APRIL; CD256) is encoded by the Tnfsf13 (also known as APRIL) gene (Gene ID: 69583) in mouse. APRIL is a secreted cytokine of the tumor necrosis family and is present in T cells, B cells, dendritic cells, monocytes, and macrophages. April exists as a functional homotrimer, but can form functional heterotrimers with B cell activating factor (BAFF). APRIL stimulates T and B cell proliferation and it exerts T and B cell regulatory effects by binding to TNFRSF17 (BCMA) and TNFRSF13B (TACI) receptors. It is also involved in monocyte/macrophage-mediated immunological processes. It also plays a role in the regulation of tumor cell growth and can induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. APRIL can serve as as a potential biomarker and its serum levels are shown to be elevated for certain cancers and expression levels elevated in cancer tissues.

特異性

Clone A3D8 detects TNFSF13/APRIL in human peripheral blood mononuclear cells (PBMC).

免疫原

A full length recombinant fusion protein of murine maltose binding protein (MBP) and soluble APRIL.

應用

Detect TNFSF13 using this armenian hamster monoclonal Anti-TNFSF13 (APRIL) antibody, clone A3D8, Cat. No. MABC1031, validated for use in Flow Cytometry.

Flow Cytometry Analysis: 1 µg of this antibody from a representative lot detected TNFSF13 in one million RAW264.7 cells.

Research Category
Apoptosis & Cancer

品質

Evaluated by Flow Cytometry in human PBMC cells.

Flow Cytometry Analysis: 1 µg of this antibody detected TNFSF13 in human PBMC cells.

標靶描述

26.89 kDa calculated.

外觀

Protein G purified

Format: Purified

Purified armenian hamster monoclonal antibody IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2