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重要文件

MAB3501

Sigma-Aldrich

Anti-Caspase 2 Antibody, clone 10C6

clone 10C6, Chemicon®, from rat

同義詞:

ICH-1

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rat

品質等級

抗體表格

purified antibody

抗體產品種類

primary antibodies

無性繁殖

10C6, monoclonal

物種活性

human, monkey, canine, mouse

製造商/商標名

Chemicon®

技術

ELISA: suitable
flow cytometry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

同型

IgG2a

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... CASP2(835)

特異性

MAB3501 antibody recognizes a reactive epitope that lies in the P19 subunit of human Caspase-2 (ICH-1, Nedd-2).

免疫原

Raised against the P19 subunit of recombinant human Caspase-2 protein.

應用

Anti-Caspase 2 Antibody, clone 10C6 detects level of Caspase 2 & has been published & validated for use in ELISA, FC, IP & WB.
Research Category
Apoptosis & Cancer

Metabolism
Research Sub Category
Caspases

Enzymes & Biochemistry
Western blot: Recommended usage at 5 μg/ml, which has been found to detect endogenous Caspase-2 in 5 x 10E5 HeLa and MCF-7 cells.

Immunoprecipitation: Recommended concentration 1-5 μg/ml FACS: Recommended concentration 1 μg/ml. It is necessary to permeabilize the cell membrane prior to analysis.

EIA: Recommended concentration 0.5-1 μg/ml.

Immunohistochemistry: Use at 10-20 μg/ml. It is necessary to fix the cells in 4% Paraformaldehyde/0.18% Triton-X100 for 10 minutes prior to staining.

Optimal working dilutions must be determined by end user.

聯結

Replaces: 04-571

外觀

Format: Purified
Purified rat monoclonal antibody in buffer containing PBS, 0.1% Kathon.

儲存和穩定性

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律資訊

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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象形圖

Exclamation markEnvironment

訊號詞

Warning

危險分類

Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

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您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

M Seervi et al.
Cell death & disease, 2, e207-e207 (2011-09-09)
Mitochondrial cytochrome c (cyt. c) release and caspase activation are often impaired in tumors with Bcl-2 overexpression or Bax and Bak-defective status. Direct triggering of cell death downstream of Bax and Bak is an attractive strategy to kill such cancers.
Grace X Y Zheng et al.
PLoS genetics, 7(5), e1002054-e1002054 (2011-05-17)
MicroRNAs (miRNAs) post-transcriptionally regulate the expression of thousands of distinct mRNAs. While some regulatory interactions help to maintain basal cellular functions, others are likely relevant in more specific settings, such as response to stress. Here we describe such a role
BH3-only protein BIM mediates heat shock-induced apoptosis.
Mahajan, IM; Chen, MD; Muro, I; Robertson, JD; Wright, CW; Bratton, SB
Testing null
Girish Neelakanta et al.
PloS one, 7(3), e33447-e33447 (2012-03-20)
Drosophila melanogaster experience cold shock injury and die when exposed to low non-freezing temperatures. In this study, we generated transgenic D. melanogaster that express putative Ixodes scapularis antifreeze glycoprotein (IAFGP) and show that the presence of IAFGP increases the ability
M Mancini et al.
The Journal of cell biology, 149(3), 603-612 (2000-05-03)
Caspases are an extended family of cysteine proteases that play critical roles in apoptosis. Animals deficient in caspases-2 or -3, which share very similar tetrapeptide cleavage specificities, exhibit very different phenotypes, suggesting that the unique features of individual caspases may

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