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Key Documents

MAB2511

Sigma-Aldrich

Anti-VCAM-1 Antibody, clone P8B1

clone P8B1, Chemicon®, from mouse

同義詞:

CD106

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

mouse

品質等級

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

P8B1, monoclonal

物種活性

human

製造商/商標名

Chemicon®

同型

IgG2b

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

特異性

MAB2511 recognizes the human VCAM-1 molecule. The antibody inhibits VLA-4 (integrin alpha4beta1) binding and recognizes a different epitope than that which is recognized by MAB2144 (P3C4 clone).

應用

Anti-VCAM-1 Antibody, clone P8B1 detects level of VCAM-1 & has been published & validated.
Function blocking

Optimal working dilutions must be determined by end user.

外觀

Format: Purified
Purified immunoglobulin. Liquid in 0.2 M phosphate buffer to 0.25 M NaCl, pH 7.6 with 0.1% sodium azide. Caution: Sodium azide is toxic. See online MSDS.

儲存和穩定性

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.

During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container′s cap.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律資訊

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

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Max L B Grönloh et al.
EMBO reports, 24(1), e55483-e55483 (2022-11-17)
Upon inflammation, leukocytes leave the circulation by crossing the endothelial monolayer at specific transmigration "hotspot" regions. Although these regions support leukocyte transmigration, their functionality is not clear. We found that endothelial hotspots function to limit vascular leakage during transmigration events.
Thomas D Manes et al.
Arteriosclerosis, thrombosis, and vascular biology, 36(9), 1910-1918 (2016-07-23)
Circulating human T effector memory cell (TEM) recognition of nonself MHC (major histocompatibility complex) molecules on allograft endothelial cells can initiate graft rejection despite elimination of professional antigen-presenting cells necessary for naive T-cell activation. Our previous studies of CD4 TEM
Barbara Garmy-Susini et al.
The Journal of clinical investigation, 115(6), 1542-1551 (2005-05-20)
Neovascularization depends on vascular cell proliferation and on the stabilization of vessels by association of vascular smooth muscle-like pericytes with ECs. Here we show that integrin alpha4beta1 (VLA-4) and VCAM-1 promote close intercellular adhesion between ECs and pericytes and that

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