HTMP1MAG-54K

MILLIPLEX^® Human TIMP Magnetic Bead Panel 1 - Immunology Multiplex Assay

TIMP Bead-Based Multiplex Assays using the Luminex technology enables the simultaneous analysis of multiple TIMP biomarkers in human serum, plasma and cell culture samples.

• 分類程式碼代碼: 12161503
• eCl@ss: 32161000
• NACRES: NA.84

屬性

• 品質等級: 200
• 物種活性: human
• 製造商／商標名: Milliplex^®
• assay range: accuracy: 92-101%; standard curve range: 20-20,000 pg/mL; (TIMP-1); standard curve range: 49-50,000 pg/mL; (TIMP-2)
• 技術: multiplexing: suitable
• 檢測方法: fluorometric (Luminex xMAP)
• 運輸包裝: wet ice

描述

一般說明

Tissue Inhibitors of Metalloproteinases (TIMPs) comprise a family of four inhibitors known as TIMP-1, TIMP-2, TIMP-3, and TIMP-4. Each member of the TIMP family has its own distinct profile of metalloproteinase inhibition. The matrix metalloproteinases (MMPs) are a family of zinc proteases involved in the breakdown of extracellular matrix (ECM) in normal physiological processes, such as embryonic development, tissue and bone remodeling, wound healing, tissue morphogenesis, angiogenesis, and tumor metastasis. MMPs are also known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), cell proliferation, differentiation, and chemokine in/activation. The normal function of MMPs must be precisely regulated by their endogenous protein inhibitors, TIMPs . TIMPs inhibit MMPs by forming 1:1, non-covalent complexes with MMPs, thereby blocking access of substrates to the MMP catalytic site. Except for inhibition of active MMPs, TIMPs also exhibit several other biochemical and physiological/biological functions such as proMMP activation, cell growth promotion, matrix binding, inhibition of angiogenesis and the induction of apoptosis. Disruption of the MMP/TIMP balance can result in serious diseases such as arthritis, cardiovascular disorders, tumor growth and metastasis.

The MILLIPLEX^® Human TIMP Panel 1 Bead kit (TIMP-1, -2) is to be used for serum/plasma samples.

The Luminex^® xMAP^® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Cytokines/Chemokines

特異性

Cross Reactivty
No significant cross-reactivity was observed among analytes in this panel.

應用

• Analytes: TIMP-1, TIMP-2
• Recommended Sample type: Serum or plasma
• Recommended Sample dilution: 1:50
• Assay Run Time: One day or overnight
• Research Category: Inflammation & Immunology

特點和優勢

Design your multiplex kit by choosing available analytes within this panel.

儲存和穩定性

Recommended storage for kit components is 2 - 8°C.

其他說明

Sensitivity: Refer to kit protocol for sensitivities of individual analytes.

法律資訊

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 象形圖: GHS07,GHS09
• 訊號詞: Warning
• 危險聲明: H302 + H312 + H332,H315,H317,H319,H335,H411
• 防範說明: P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• 危險分類: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 10 - Combustible liquids