HCABMAG-13K

MILLIPLEX^® Human Cancer Autoantibody Magnetic Bead Panel - Cancer Multiplex Assay

• 分類程式碼代碼: 12161503
• NACRES: NA.41

屬性

• 物種活性: human
• 製造商／商標名: Milliplex^®
• 技術: multiplexing: suitable
• assay range: inter-assay cv: <20%; intra-assay cv: <10%
• 檢測方法: fluorometric (Luminex^® xMAP^®)
• 儲存溫度: 2-8°C

描述

一般說明

Cancer autoantibodies have been studied as reporters of early carcinogenesis and indicators of cancer prognosis. Autoantibodies to tumor-associated antigens are putative cancer biomarkers, as these autoantibodies are abundant, detectable in early stages, and stable in serum. These autoantibodies may be developed from humoral immune responses to the changes in the expression levels of tumor-associated self-antigens, misfolded proteins, mutant antigens, and proteins involved in inflammation and the cellular death process. While the frequency of cancer autoantibody responses to an individual tumor antigen is typically low, the response to a multiplexed panel of antigens could be much higher. An optimized multiplex autoantibody panel to common tumor-associated antigens can improve the potential of using autoantibodies as biomarkers to study cancer development and progression, and it can serve as a simple and affordable tool in evaluating large numbers of patient samples for multiple cancer types.
The MILLIPLEX^® MAP Human Cancer Autoantibody Magnetic Bead Panel is a 15-plex kit to be used for the simultaneous quantification of autoantibodies to any or all of the following analytes in serum and plasma samples: Alpha-enolase (ENO1), Cancer/Testis Antigen 1B (CTAG1B/NY-ESO-1), Cyclin-dependent kinase 4 inhibitor A (p16-INK4a), G2/mitotic-specific cyclin-B1 (CCNB1), Galactose-specific lectin-1 (Galectin 1), Galactose-specific lectin-3 (Galectin 3), Heat shock protein 60 (HSP60), Hypoxia-inducible factor 1-alpha (HIF1α), Insulin-like growth factor 2 mRNA-binding protein 2 (IMP-2), Insulin-like growth factor 2 mRNA-binding protein 3 (IMP-3), Mucin 1 (MUC1), Receptor tyrosine-protein kinase (HER2/ErbB2), sex determining region Y (SRY)-box 2 (SOX2), Survivin (Survivin/BIRC5), and Tumor protein p53 (p53). For this particular panel, four assay control beads are included as part of the base kit format.

應用

• Analytes Available: CCNB1/Cyclin B1, CTAG1B/NY-ESO-1, ENO1, Galectin-1 (GAL1), Galectin-3, ErbB2/HER2, HIF-1α, HSP60, IGF2BP2/IMP2, IGF2BP3/IMP3, Mucin-1 (MUC1), P16-INK4a, p53, Sox2, Survivin/BIRC5.
• Panel Type: MAGNETIC Circulating Cancer
• This is assay yields results in Median Fluorescence Intensity (MFI).
• Four assay control beads are included in the base kit.
• This is an overnight assay.
• Recommended dilution: This assay requires 25 μL of 1:100 diluted plasma or serum.
• Research Category: Oncology
• Research Sub-Category: Oncology, Tumor Markers, Immune Response

特點和優勢

Design your multiplex kit by choosing available analytes within this panel.

儲存和穩定性

Recommended storage for kit components is 2 - 8°C.

法律資訊

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 象形圖: GHS07,GHS09
• 訊號詞: Warning
• 危險聲明: H317,H319,H411
• 防範說明: P261 - P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1
• 儲存類別代碼: 12 - Non Combustible Liquids
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable