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Key Documents

ABS524

Sigma-Aldrich

Anti-Lipin-2 Antibody

from rabbit, purified by affinity chromatography

同義詞:

Phosphatidate phosphatase LPIN2, Lipin-2

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

純化經由

affinity chromatography

物種活性

mouse

技術

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

mouse ... Lpin2(64898)

相關類別

一般說明

Lpin2, also known as Phosphatidate phosphatase LPIN2, and encoded by the gene Lpin2, plays important roles in controlling the metabolism of fatty acids. Lpin2 acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Lpin2 also acts as a nuclear transcriptional coactivator for PGC-1α protein. Lpin2 is localized to the cytoplasm and endoplasmic reticulum membrane but is also found in the nucleus. Lpin2 is expressed in many cells and tissues including liver, lung, kidney, placenta, prostate, and intestine. Expression is also seen in RBCs and at sites of lymphopoiesis in bone and spleen. Homozygous mutations in LPIN2 result in Majeed syndrome. Majeed syndrome is an autosomal recessive, autoinflammatory disorder characterized by chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anemia.

免疫原

Linear peptide corresponding to mouse Lipin-2.

應用

Anti-Lipin-2 Antibody is an antibody against Lipin-2 for use in western blotting, IHC & IP.
Research Category
Signaling
Research Sub Category
Lipid Metabolism & Weight Regulation
Western Blotting Analysis: A representative lot detected Lipin-2 in mouse WAT cell lysate (Gropler, M. C., et al. (2008). JBC. 284(11):6763-6772).
Immunocytochemistry Analysis: A representative lot detected Lipin-2 in mouse cerebellum tissue (Mayurranjan, S., et al. (2013). PNAS. 110(2):642-647).

品質

Evaluated by Western Blotting in mouse hepatocytes cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Lipin-2 in 10 µg of mouse hepatocytes cell lysate.

標靶描述

~ 110 kDa observed

外觀

Affinity purified
Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide with 50% glycerol.

儲存和穩定性

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

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Matthew C Gropler et al.
The Journal of biological chemistry, 284(11), 6763-6772 (2009-01-13)
Lipin 1 is a bifunctional intracellular protein that regulates fatty acid metabolism in the nucleus via interactions with DNA-bound transcription factors and at the endoplasmic reticulum as a phosphatidic acid phosphohydrolase enzyme (PAP-1) to catalyze the penultimate step in triglyceride
Jingquan He et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(7), 2893-2904 (2017-03-30)
Cancer cells reprogram their metabolism to increase the synthesis of macromolecules for rapid proliferation. Compared to fatty acids, much less is known about the synthesis of phospholipids, which is essential for membrane biogenesis in cancer cells. We found that LPIN1

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