ABS1036

Anti-FMO3 Antibody

serum, from rabbit

• 同義詞: Dimethylaniline monooxygenase [N-oxide-forming] 3, Dimethylaniline oxidase 3, FMO form 2, FMO 3, FMO II, Hepatic flavin-containing monooxygenase 3, Trimethylamine monooxygenase
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: serum
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 物種活性: human
• 物種活性（以同源性預測）: chimpanzee (based on 100% sequence homology)
• 技術: immunohistochemistry: suitable; western blot: suitable
• NCBI登錄號: NP_001002294
• UniProt登錄號: P31513
• 運輸包裝: dry ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... FMO3(2328)

描述

一般說明

Dimethylaniline monooxygenase [N-oxide-forming] 3 (EC 1.14.13.8; EC 1.14.13.148; UniProt P31513; also known as Dimethylaniline oxidase 3, FMO form 2, FMO 3, FMO II, Hepatic flavin-containing monooxygenase 3, Trimethylamine monooxygenase) is encoded by the FMO3 (also known as FMOII, TMAU) gene (Gene ID 2328) in human. Flavin-containing mono-oxygenases (FMOs) constitute a family of microsomal chemical- and drug-metabolizing enzymes, with FMO3 being a major form in adult mouse and human liver. FMO3 is responsible for N-oxidation of a malodorous metabolite, trimethylamine (TMA), to the non-odorous trimethylamine N-oxide (TMAO). FMO3 mutations cause trimethylaminuria (TMAU or Fish odor syndrome), a rare inherited disorder due to decreased metabolism of dietary-derived TMA. More than 300 single nucleotide polymorphisms of the human FMO3 have been reported and over 40 of these polymorphisms have been linked to TMAU. 17β-estradiol-dependent ERα activation is reported to play a fundamental role in the regulation of FMO3 gene transcription.

免疫原

Epitope: Internal (N-terminal half).

Linear peptide corresponding to an internal sequence from the N-terminal half of human FMO3.

應用

Detect FMO3 using this Anti-FMO3 Antibody validated for use in Western Blotting, Immunohistochemistry.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FMO3 in human liver tissue.

Research Category
Signaling

Research Sub Category
Toxicology & Drug Resistance

品質

Evaluated by Western Blotting in human liver microsomal tissue lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected FMO3 in 10 µg of human liver microsomal tissue lysate.

標靶描述

~55 kDa observed. 59.96 kDa calculated.

外觀

Unpurified

Rabbit polyclonal serum with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable