ABN88
Anti-phospho-NR1 (Ser896) Antibody
from rabbit, purified by affinity chromatography
同義詞:
glutamate receptor, ionotropic, N-methyl D-aspartate 1, glutamate [NMDA] receptor subunit zeta 1, N-methyl-D-aspartate receptor channel, subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1, glutamate [NMDA] receptor subunit zeta-1
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About This Item
分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41
無性繁殖:
polyclonal
application:
IHC
WB
WB
物種活性:
rat
技術:
immunohistochemistry: suitable (paraffin)
western blot: suitable
western blot: suitable
citations:
8
推薦產品
生物源
rabbit
品質等級
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
純化經由
affinity chromatography
物種活性
rat
物種活性（以同源性預測）
mouse (based on 100% sequence homology), human (based on 100% sequence homology)
技術
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
phosphorylation (pSer896)
基因資訊
human ... GRIN1(2902)
mouse ... Grin1(14810)
rat ... Grin1(24408)
一般說明
NR1 (NMDA1or NMDAR1, also known as GRIN1) along with the NR2 subunit forms a heterodimer that make up the NMDA receptor. The NMDA receptor (NMDAR) is characterized as a ionotropic receptor for glutamate. As the name suggests, (NMDA (N-methyl D-aspartate) is an agonist for the receptor. A distinct characteristic of the NMDA receptor is that it is both ligand-gated and voltage-dependent based on its sensitivity to magnesium. Activated NMDA receptors result in the opening of an ion channel that is nonselective to cations. The result is the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell. Calcium flux by the NMDARs has been implicated in synaptic plasticity, a mechanism in the cell for learning and memory.
特異性
This antibody recognizes NR1 when phosphorylated at Ser896.
免疫原
Epitope: Phosphorylated Ser896
KLH-conjugated linear peptide corresponding to rat NR1 phosphorylated at Ser896.
應用
Detect phospho-NR1 (Ser896) using this Anti-phospho-NR1 (Ser896) Antibody validated for use in WB, IH(P).
Immunohistochemistry Analysis: 1:25 dilution from a previous lot detected NR1 in normal rat hippocampus tissue.
品質
Evaluated by Western Blot in lambda phosphatase untreated and treated rat microsomal brain tissue lysates.
Western Blot Analysis: 1 µg/mL of this antibody detected NR1 on 10 µg of lambda phosphatase untreated and treated rat microsomal brain tissue lysates.
Western Blot Analysis: 1 µg/mL of this antibody detected NR1 on 10 µg of lambda phosphatase untreated and treated rat microsomal brain tissue lysates.
標靶描述
~130kDa observed
聯結
Replaces: 06-640
分析報告
Control
Lambda phosphatase untreated and treated rat microsomal brain tissue lysates
Lambda phosphatase untreated and treated rat microsomal brain tissue lysates
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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儲存類別代碼
10-13 - German Storage Class 10 to 13
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Jing-Dun Xie et al.
The Journal of biological chemistry, 291(37), 19364-19373 (2016-07-28)
Painful peripheral neuropathy is a severe adverse effect of chemotherapeutic drugs such as paclitaxel (Taxol). The glutamate N-methyl-d-aspartate receptors (NMDARs) are critically involved in the synaptic plasticity associated with neuropathic pain. However, paclitaxel treatment does not alter the postsynaptic NMDAR
Milena De Felice et al.
Molecular pain, 12 (2016-04-21)
Bone metastases occur frequently in advanced breast, lung, and prostate cancer, with approximately 70% of patients affected. Pain is a major symptom of bone metastases, and current treatments may be inadequate or have unacceptable side effects. The mechanisms that drive
Sheu-Ran Choi et al.
Experimental neurobiology, 28(4), 516-528 (2019-09-09)
We have previously demonstrated that the neurosteroid dehydroepiandrosterone sulfate (DHEAS) induces functional potentiation of N-methyl-D-aspartate (NMDA) receptors via increases in phosphorylation of NMDA receptor GluN1 subunit (pGluN1). However, the modulatory mechanisms responsible for the expression of the DHEA-synthesizing enzyme, cytochrome
Sheu-Ran Choi et al.
Biological & pharmaceutical bulletin, 39(12), 1922-1931 (2016-09-08)
We recently demonstrated that activation of spinal sigma-1 receptors (Sig-1Rs) induces pain hypersensitivity via the activation of neuronal nitric oxide synthase (nNOS) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (Nox2). However, the potential direct interaction between nNOS-derived nitric oxide
Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G??A ALS mice: overlapping effects or limited therapeutic opportunity?
Mancuso, R; Del Valle, J; Morell, M; Pallas, M; Osta, R; Navarro, X
Orphanet Journal of Rare Diseases null
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