ABS457

Anti-ASAH2 Antibody

from rabbit, purified by affinity chromatography

• 同義詞: N-acylsphingosine amidohydrolase, Non-lysosomal ceramidase 2, HNAC1, Neutral ceramidase, Acylsphingosine deacylase 2, ASAH2
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human
• 技術: western blot: suitable
• UniProt登錄號: Q9NR71
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... ASAH2(56624)

描述

一般說明

N-acylsphingosine amidohydrolase 2 (ASAH2), also known as neutral ceramidase (N-CDase, NCDase), is a key regulator of sphingolipid signaling metabolites. ASAH2 is known to hydrolyze the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Additionally, ASAH2 is suggested to act as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. ASAH2 is also suggested to be involved in the digestion of dietary sphingolipids in intestine tract. In this role, ASAH2 is implied to act as a key enzyme for the catabolism of dietary sphingolipids and consequently, regulating the levels of bioactive sphingolipid metabolites in the intestinal tract. ASAH2 is expressed primarily in the intestine. It is also expressed with higher levels in kidney, skeletal muscle and heart.

免疫原

KLH-conjugated linear peptide corresponding to human ASAH2.

應用

Anti-ASAH2 Antibody is a highly specific rabbit polyclonal antibody, that targets ASAH2 & has been tested in western blotting.

Research Category
Signaling

Research Sub Category
Developmental Signaling

品質

Evaluated by Western Blotting in HEK293 cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected ASAH2 in 15 µg of HEK293 cell lysate.

標靶描述

~70 kDa observed. Uniprot describes 2 isoforms at ~82 kDa and ~86 kDa Uncharacterized bands may appear in some lysate(s).

外觀

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
HEK293 cell lysate

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable