ABN1389

Anti-MARCO

from rabbit, purified by affinity chromatography

• 同義詞: Macrophage receptor with collagenous structure, Scavenger receptor class A member 2
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human, mouse
• 技術: western blot: suitable
• NCBI登錄號: NP_006761
• UniProt登錄號: Q9UEW3
• 運輸包裝: ambient
• 目標翻譯後修改: unmodified
• 基因資訊: human ... MARCO(8685)

描述

一般說明

Macrophage receptor MARCO (UniProt: Q9UEW3; also known as macrophage receptor with collagenous structure; Scavenger receptor class A member 2) is encoded by the MARCO (also known as SCARA2) gene (Gene ID: 8685) in human. MARCO is strongly expressed in macrophages of several tissues in humans with sepsis. It is a scavenger receptor that is readily upregulated following bacterial infection. Hence, it forms a back-up system through which the organism can quickly arm more cells with highly efficient phagocytosing receptors. MARCO is a single-pass type II membrane protein that binds both Gram-positive and Gram-negative bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. The bacteria-binding region is localized immediately proximal to the cysteine-rich region of domain V. Human and mouse MARCO exhibit about 68% sequence identity. However, the human MARCO subunit chain differs from the mouse chain in that it does not have any cysteine residues outside the cysteine-rich domain V, whereas the mouse chain has one cysteine residue within the intracellular domain I and two in the extracellular spacer domain III. (Ref.: Elomaa, O., et al. (1998). J. Biol. Chem. 273(8): 4350-4538).

特異性

This polyclonal antibody detects macrophage receptor MARCO in RAW264.7 cells.

免疫原

KLH-cojugated peptide corresponding to 12 amino acids from the C-terminal region of human MARCO.

應用

Anti-MARCO, Cat. No. ABN1389, is a highly specific rabbit polyclonal antibody that targets Macrophage receptor MARCO and has been tested in Western Blotting.

Research Category
Neuroscience

Western Blotting Analysis: A 1:500 dilution from a representative lot detected MARCO in 10 µg of A549 cell lysate.

品質

Evaluated by Western Blotting in RAW264.7 cells.

Western Blotting Analysis (WB): A 1:5000 Dilution of this antibody detected Macrophage receptor MARCO in 10 µg RAW264.7 cells .

標靶描述

~60 kDa observed; 52.65 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

外觀

Affinity Purified

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1