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生物源
rabbit
品質等級
抗體表格
purified immunoglobulin (Partially purified)
抗體產品種類
primary antibodies
無性繁殖
polyclonal
物種活性
human, mouse
製造商／商標名
Chemicon®
技術
immunohistochemistry: suitable
western blot: suitable
輸入
sample type hematopoietic stem cell(s)
sample type neural stem cell(s)
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... DVL2(1856)
mouse ... Dvl2(13543)
一般說明
DVL2 is a member of multigene family that also contains DVL1 and DVL3. The vertebrate dishevelled proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. DVL2 encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein.
特異性
Disheveiled-2 protein (dvl-2). By Western blot the antibody shows no cross reactivity with recombinant disheveiled-1 (dvl-1) or disheveiled-3 (dvl-3) protein. Pre-adsorption of the antibody with the immunogen peptide completely abolishes its reactivity by Western blot against disheveiled-2 protein.
免疫原
Synthetic peptide corresponding to amino acids 600-614 of human and mouse disheveiled-2 protein.
應用
Detect Dishevelled-2 using this Anti-Dishevelled-2 Antibody validated for use in WB, IH.
Research Category
Stem Cell Research
Stem Cell Research
Research Sub Category
Hematopoietic Stem Cells
Neural Stem Cells
Hematopoietic Stem Cells
Neural Stem Cells
Western blot: 1:1,000 using ECL. The antibody reacts with a protein of ~95kDa. Faint reactivity was seen in the dvl-1 and dvl-3 HEK293 cell lysates suggesting there may be endogenous dvl-2 present.
Immunohistochemistry: 1:1,000 using the avidin-biotin system.
Dilute antibody in 50 mM PBS, pH 7.4 containing 1.5% sodium chloride and 1% normal animal serum (same species as the host of the secondary antibody).
Optimal working dilutions must be determined by end user.
Immunohistochemistry: 1:1,000 using the avidin-biotin system.
Dilute antibody in 50 mM PBS, pH 7.4 containing 1.5% sodium chloride and 1% normal animal serum (same species as the host of the secondary antibody).
Optimal working dilutions must be determined by end user.
標靶描述
80 kDa
外觀
Format: Purified
Partially purified immunoglobulin. Liquid in PBS, pH 7.4, containing 0.01M sodium azide.
儲存和穩定性
Maintain at -20°C in undiluted aliquots (not less than 10 μL) for up to 6 months. Avoid repeated freeze/thaw cycles. The use of high quality antiserum-grade plastic or glass is recommended.
分析報告
Control
SK-N-SH (human neuroblastoma) whole cell lysates, NIH 3T3 whole cell lysate, BT-20 (human mammary gland) cell lysate, FP (mouse embryonal carcinoma
testicular teratoma) cell lysate
SK-N-SH (human neuroblastoma) whole cell lysates, NIH 3T3 whole cell lysate, BT-20 (human mammary gland) cell lysate, FP (mouse embryonal carcinoma
testicular teratoma) cell lysate
法律資訊
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Glycogen synthase kinase-3beta immunoreactivity is reduced in the prefrontal cortex in schizophrenia.
Beasley, C, et al.
Neuroscience Letters, 302, 117-120 (2001)
Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer.
Metcalfe, C; Ibrahim, AE; Graeb, M; de la Roche, M; Schwarz-Romond, T; Fiedler, M; Winton et al.
Cancer Research null
Dong Chen et al.
Molecular medicine reports, 11(3), 2092-2096 (2014-11-15)
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Teodoro Pulvirenti et al.
Cancer research, 71(23), 7280-7290 (2011-10-13)
Glioblastoma multiforme is the most common glioma variant in adults and is highly malignant. Tumors are thought to harbor a subpopulation of stem-like cancer cells, with the bulk resembling neural progenitor-like cells that are unable to fully differentiate. Although multiple
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