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AB10911

Sigma-Aldrich

抗骨钙素抗体

serum, from rabbit

同義詞:

Bone Gla protein, Gamma-carboxyglutamic acid-containing protein, bone gamma-carboxyglutamate (gla) protein (osteocalcin)

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

抗體表格

serum

抗體產品種類

primary antibodies

無性繁殖

polyclonal

物種活性

human, rat, mouse

技術

immunohistochemistry: suitable
western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... BGLAP(632)
mouse ... Bglap(12096)
rat ... Bglap(25295)

一般說明

骨钙素属于骨钙素/基质Gla蛋白家族。占骨蛋白总量的1~2%。它由成骨细胞制成,是非胶原骨基质的主要成分。它对钙具有高亲和力,并与磷灰石牢固结合。60%至90%的从头合成的骨钙素被掺入骨基质中,在基质矿化过程中它与羟基磷灰石结合。骨钙素的其余部分释放到循环中,可以作为骨形成的敏感标志物进行测量。血清中发现的骨钙素几乎完全来自骨形成,而吸收过程几乎没有贡献。主要作用于骨吸收的药物,例如双膦酸盐,会引起特定骨吸收标志物的快速下降,而骨钙素水平仅在延长治疗期后才会发生变化,这与骨形成标志物的预期动力学一致。在以骨转换增加为特征的疾病(例如骨质疏松症症、甲状旁腺功能亢进症症和Paget′s病)中,血清骨钙素水平升高;在与骨转换减少相关的疾病(例如甲状旁腺功能减退症症和生长激素缺乏症症)中,血清骨钙素水平降低。

特異性

抗体与骨钙素蛋白反应。

免疫原

合成肽对应于骨钙素蛋白的aa 59-74。
表位:aa 59-74

應用

使用经过验证可用于WB、IH的抗骨钙素抗体检测骨钙素。

品質

通过蛋白质印迹法对人心脏裂解液进行常规评估。

蛋白质印迹分析:
该抗体的1:500 - 1:5,000稀释液在10 μg人心脏裂解液中检测到骨钙素。

標靶描述

计算值为11 kDa。
*观察到约22 kDa的条带。观察到的条带与预期条带之间的差异可能是由于翻译后修饰所致。

聯結

替代品:MABD182

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1


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