SAB4200018

Anti-Osteopontin antibody, Mouse monoclonal

clone OPN46, purified from hybridoma cell culture

• 同義詞: Anti-BNSP, Anti-Bone Sialoprotein 1, Anti-Early T Lymphocyte Activation Protein 1 (ETA1), Anti-OPN, Anti-SPP1, Anti-Secreted phosphoprotein 1, Anti-Urinary stone protein, Anti-Uropontin
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: mouse
• 共軛: unconjugated
• 抗體表格: purified from hybridoma cell culture
• 抗體產品種類: primary antibodies
• 無性繁殖: OPN46, monoclonal
• 形狀: buffered aqueous solution
• 分子量: antigen ~60 kDa
• 物種活性: human, mouse, monkey, rat, canine
• 濃度: ~1.0 mg/mL
• 技術: western blot: 5-10 μg/mL using HepG2 cells extract
• 同型: IgG1
• UniProt登錄號: P10451
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... SPP1(6696)

描述

一般說明

Monoclonal Anti-Osteopontin (mouse IgG1 isotype) is derived from the hybridoma OPN46 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to amino acids of human osteopontin. Osteopontin (OPN) is a secreted, integrin-binding glycophosphoprotein which serves as a cytokine and as an extracellular matrix molecule. It is produced by multiple tissues in the body and is most abundant in bone.

應用

Monoclonal Anti-Osteopontin antibody produced in mouse may be used in immunoblotting.

生化／生理作用

Osteopontin (OPN) synthesized in cancer cells is essentail for growth, progression and metastasis of cancer. In tuomr cells OPN is highly expressed The structural features of OPN differ between normal and tumor cells Three osteopontin splice variant transcripts have been found to be expressed in invasive, but not in non-invasive breast tumor cell lines. Osteopontin-b lacks exon 5 and osteopontin-c lacks exon 4. The shortest splice variant, osteopontin-c may support breast tumor progression by conveying anchorage independence and inducing oxidoreductases expression. It was also suggested as a diagnostic and prognostic breast cancer marker.

外觀

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable