8.55072

p-Nitrophenyl carbonate Merrifield resin

Novabiochem^®

• 分類程式碼代碼: 12352005
• NACRES: NA.22

屬性

• 品質等級: 200
• 產品線: Novabiochem^®
• 形狀: beads
• 反應適用性: reaction type: Fmoc solid-phase peptide synthesis; reactivity: amine reactive
• 製造商／商標名: Novabiochem^®
• 應用: peptide synthesis
• 儲存溫度: 15-25°C

描述

一般說明

Resin-bound p-nitrophenyl carbonate esters react readily with amines to provide the corresponding resin-bound carbamate. Leznoff ^[1] was the first to demonstrate the utility of such resins in solid phase synthesis with the preparation of mono-acylated diamines from symmetrical diamines. Dress man, et al. ^[2] have used carbamate linked resin-bound amino acid amides to make hydantoins via a base-mediated cyclization/ cleavage strategy; a similar approach has also been used to prepare quinazolidine-2,4-diones ^[3]. Gordon, et al. ^[4] have used p-nitrophenyl carbonate Merrifield resin to immobilize a ketone linker through a phenyl carbonate linkage. Loading of this resin can be quantified by measuring the release of p-nitrophenolate ^[5].

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

^[1] D. M. Dixit, et al. (1978) Israel J. Chem., 17, 248.
^[2] B. A. Dressman, et al. (1996) Tetrahedron Lett., 37, 937.
^[3] L. Gouilleux, et al. (1996) Tetrahedron Lett., 37, 7031.
^[4] K. Gordon, et al. (2000) Tetrahedron Lett., 41, 8621.
^[5] A. Paio, et al. (2003) Tetrahedron Lett.,44, 1867.

聯結

Replaces: 01-64-0131

分析報告

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (photometric determination of p-nitrophenyl released upon treatment with piperidin): 0.80 - 1.40 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly ( styrene - 1% DVB ), 100 - 200 mesh

法律資訊

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable