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重要文件

688225

Sigma-Aldrich

Caspase-1 Substrate VI, Fluorogenic

Fluorogenic caspase-1 substrate.

同義詞:

Caspase-1 Substrate VI, Fluorogenic, Z-YVAD-AFC

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About This Item

經驗公式(希爾表示法):
C33H36F3N5O10
CAS號碼:
分子量::
719.66
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

化驗

98% (HPLC)

形狀

solid

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
desiccated
protect from light

顏色

white to off-white

溶解度

DMSO: 5 mg/mL

螢光

λex ~400 nm
λem ~505 nm

運輸包裝

ambient

儲存溫度

−20°C

SMILES 字串

FC(F)(F)c1c2c([o][c](c1)=O)cc(cc2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)Cc3ccc(cc3)O)C(C)C)C)CC(=O)O

InChI

1S/C33H36F3N5O10/c1-15(2)28(41-31(49)23(38-17(4)42)11-18-5-8-20(43)9-6-18)32(50)37-16(3)29(47)40-24(14-26(44)45)30(48)39-19-7-10-21-22(33(34,35)36)13-27(46)51-25(21)12-19/h5-10,12-13,15-16,23-24,28,43H,11,14H2,1-4H3,(H,37,50)(H,38,42)(H,39,48)(H,40,47)(H,41,49)(H,44,45)/t16-,23-,24-,28-/m0/s1

InChI 密鑰

GWKJISJKNKIJNP-DEQDFGQZSA-N

一般說明

Fluorogenic ICE substrate. Reaction can be monitored by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore. AFC (7-amino-4-trifluoromethylcoumarin) based fluorometric substrates are superior to AMC (7-amino-4-methylcoumarin) substrates because released AFC has a greater Stoke′s shift than AMC. Excitation/emission maxima (nm) for AFC and AMC are 400/505 and 380/460, respectively.
Fluorogenic caspase-1 substrate. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.

生化/生理作用

Cell permeable: no
Primary Target
Fluorogenic caspase-1 substrate
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

序列

Ac-Tyr-Val-Ala-Asp-AFC

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Jones, R.A., et al. 1998. Hepatology 27, 1632.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Walker, N.P., et al. 1994. Cell 78, 343.
Thornberry, N.A., et al. 1992. Nature 356, 768.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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