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627610

Sigma-Aldrich

Z-VAD-FMK

Single spot by TLC, solid, Caspase inhibitor, Calbiochem

同義詞:

半胱天冬酶抑制剂I, Z-VAD (OMe)-FMK

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About This Item

經驗公式（希爾表示法）:
C22H30FN3O7
CAS號碼:
187389-52-2
分子量：:
467.49
MDL號碼:
MFCD02684037
分類程式碼代碼:
12352200
NACRES:
NA.77

產品名稱

半胱天冬酶抑制剂I, Z-VAD-FMK, CAS 187389-52-2, is a cell-permeable, irreversible, pan-caspase inhibitor.

品質等級

100

形狀

solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
desiccated

顏色

white

溶解度

DMSO: 50 mM

運輸包裝

ambient

儲存溫度

−20°C

SMILES 字串

FCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C)CC(=O)OC

InChI

1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1

InChI 密鑰

MIFGOLAMNLSLGH-QOKNQOGYSA-N

一般說明

一种细胞可渗透、不可逆的泛半胱天冬酶抑制剂。显示可提高人类胚胎干细胞的冻融存活率。抑制Jurkat T细胞中Fas介导的细胞凋亡。据报道，它也抑制肽：体外和体内的N-聚糖酶 (PNGase)。当与纯化的重组酶一起使用时，需要用酯酶进行预处理。

生化／生理作用

主靶
Fas介导的Jurkat细胞凋亡和星形孢菌素诱导的角膜上皮细胞死亡
产物不与ATP竞争。
可逆：否
细胞可渗透性：是

警告

毒性：标准处理（A）

序列

Z-Val-Ala-Asp(OMe)-CH₂F*

重構

复溶后，等分并冷冻保存（-20°C）。贮备溶液可在-20°C稳定6个月。

分析報告

TLC 单点

其他說明

Heng, B.C., et al. 2007.Biosci.Rep.27, 257.
Martin, U., et al. 2007.Apoptosis12, 525.
Misaghi, S., et al. 2004.Chem. Biol.11, 1677.
Joo, C., et al. 1999.Ophthalmic Res. 31, 287.
McColl, K.S., et al. 1998.Mol.Cell.Endocrinol. 139, 229.
Thornberry, N.A. and Lazebnik, Y. 1998.Science 281, 1312.
Tolomeo, M., et al. 1998.Cell Death Differ.5, 735.
An, S. and Know, K.A. 1996.FEBS Lett.386, 115.
Cain, K., et al. 1996.Biochem J.314, 27.
Mirzoeva, O.K., et al. 1996.FEBS Lett.396, 266.
Pronk, G.J., et al. 1996.Science 271, 808.
Slee, E.A., et al. 1996.Biochem.J.315, 21.
Chow, S.C., et al. 1995.FEBS Lett.364, 134.
Fearnhead, H.O., et al. 1995.FEBS Lett.375, 283.
Zhu, H., et al. 1995.FEBS Lett.374, 303.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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